Chest
Laboratory and Animal InvestigationsHigh Expression of p40tax and Pro-inflammatory Cytokines and Chemokines in the Lungs of Human T-Lymphotropic Virus Type 1-Related Bronchopulmonary Disorders
Section snippets
Study Subjects
We examined 10 HTLV-1–seropositive individuals with lung lesions and various pulmonary symptoms (1 man and 9 women; age range, 36 to 76 years), as summarized in Table 1. HTLV-1 seropositivity was examined using the particle agglutination methods (New Seroclit-anti-HTLV-1; Sanko; Tokyo, Japan). All patients were evaluated to be in a carrier stage. Seven of the patients had chronic bronchiolitis, one patient had hypersensitivity pneumonitis diagnosed by surgical biopsy, and two patients had
Characteristics of BALF Cells
Table 3 summarizes the results BALF cell analysis in HTLV-1–infected patients and healthy control subjects. Neither leukemic cells nor pathogens associated with opportunistic infection were found in BALF of these patients. In HTLV-1–infected patients, the mean total cell count was 5.7 × 105/mL (range, 0.8 to 12.7 × 105/mL) and lymphocyte proportion was 23.4% (range, 0.6 to 53.9%; > 20% in four patients). The proportion of neutrophils ranged from 0 to 59.5%, with a mean value of 17.0%. It should
Discussion
Clinical and epidemiologic studies789101112 have established that HTLV-1 is closely associated with certain bronchopulmonary disorders. Accumulation of lymphocytes and activated T cells, as well as abundant HTLV-1–infected T cells and viral activity, have been demonstrated in BALF of HTLV-1–infected patients.891011121314151625 Although HTLV-1 was suggested to be involved in bronchopulmonary lesions, characterized by lymphocytic accumulation, the precise mechanism of such response is not fully
ACKNOWLEDGMENT
The authors thank Dr. F. G. Issa (Word-Medex; Sydney, Australia) for reading and editing the manuscript.
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