Chest
Clinical InvestigationsSLEEP AND BREATHINGConstant vs Auto-Continuous Positive Airway Pressure in Patients With Sleep Apnea Hypopnea Syndrome and a High Variability in Pressure Requirement
Section snippets
Study Design
The study protocol was approved by the Ethics Committee of the Hôpital Erasme, and all patients gave informed consent. All patients went to the sleep laboratory for baseline polysomnography and a classical CPAP titration, in order to assess an effective pressure. Treatment with CPAP at home was initiated at the chest clinic by a respiratory physician (A.N.). In the run-in period, all patients were given a machine in the auto-CPAP mode with a 4- to 14-cm H2O pressure range. The recorded data
Patients
Ninety-three patients attending the chest clinic were eligible for the study on the basis of their polysomnographic results and absence of exclusion criteria. Three patients refused CPAP as treatment at home. Of the remaining 90 patients, 27 patients had at the end of the run-in period a within-night pressure variability exceeding the required threshold (VI > 2.75 cm H2O) and were randomized. All but one were men. Their anthropometric features were as follows: age, 49 years (SD, 10); height,
Discussion
In the present study, we evaluated the GK418A device with a nose mask for home treatment, using a single-blind, randomized, cross-over design to compare auto-CPAP with constant CPAP, in 24 patients with SAHS selected on the basis of a high within-night variability in pressure requirement. We have found that a short run-in period on auto-CPAP with a large 4- to 14-cm H2O pressure range showed markedly different individual patterns in pressure requirement, and allowed for the selection of a
ACKNOWLEDGMENT
The authors thank Mrs. F. Martinez Vadillo for secretarial assistance.
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