Chest
Original Research: COPDSystemic Inflammation in Patients With COPD and Pulmonary Hypertension
Section snippets
Subjects
Patients with a diagnosis of COPD, determined according to the American Thoracic Society/European Respiratory Society guidelines,19 were consecutively recruited to the study in a university hospital setting. Exclusion criteria were respiratory disorders other than COPD, pulmonary embolism, left ventricular systolic or diastolic dysfunction, malignancy, systemic autoimmune disorders, infectious diseases, recent surgery, and severe endocrine, hepatic, or renal diseases. The study had local ethics
Patient Characteristics
Forty-three patients (29 male and 14 female) with COPD (mean age, 65.0 ± 10.5 years; range, 40 to 82 years; mean smoking history, 28.4 ± 25.9 pack-years) were recruited to the study. Fourteen patients were classified as having stage II COPD, 19 patients as having stage III COPD, and 10 patients as having stage IV COPD.19 None of the patients had a history of exposure to noxious gases (eg, diesel fumes) or biomass exposure. Pulmonary hypertension was present in 19 patients (mean systolic Ppa,
DISCUSSION
The present study provides a novel observation on the potential significance of systemic inflammation in patients with COPD who have pulmonary hypertension. Our data demonstrate that COPD patients with pulmonary hypertension have higher serum CRP and TNF-α levels compared to those with normal Ppa levels. In addition, in multiple linear regression analysis, log-transformed serum CRP level was an independent predictor of systolic Ppa. In previous studies, a relationship between Ppa and the levels
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Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (http://www.chestjournal.org/misc/reprints.shtml)
The authors have reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
This study was supported by operating grant 1/2305/05 of the Ministry of Education and by grant 2005/5-FNLPKE-01 of the Ministry of Health, Slovakia.