Chest
Original Research: SarcoidosisClinical and Radiographic Indices Associated With Airflow Limitation in Patients With Sarcoidosis
Section snippets
Study Population
The study population comprised 228 Japanese sarcoidosis patients with histologic confirmation of disease diagnosis. All patients were consecutively followed up at the outpatient sarcoidosis clinic in the Central Clinic of Kyoto. Patients with concurrent lung diseases were excluded from the study. All study subjects underwent pulmonary function tests (PFTs), and high-resolution CT (HRCT) was performed on the same day. Classification of chest radiographs (stage 0, normal; stage I, bilateral hilar
Frequency of Airflow Limitation
Twenty of the 228 subjects (8.8%) had prebronchodilator FEV1/FVC < 70%, which fulfilled the criteria of airflow limitation. Postbronchodilator increase in FEV1 ranged from − 20 to 220 mL (average, 60 mL), and percentage increase in FEV1 ranged from − 2.3 to 9.7% (average, 3.8%). Thus, all of these subjects were considered to have irreversible airflow limitation. In all of these subjects, postbronchodilator FEV1/FVC was also < 70%.
Comparison of Patient Characteristics
Patient characteristics of the study subjects are shown in Table 1
Discussion
Although pulmonary sarcoidosis mainly affects parenchyma of the lung, studies of physiologic,6, 13, 14 radiologic,15, 16, 17 and pathologic approaches2, 34, 18, 19 have revealed that airway lesions are not rare in patients with sarcoidosis. It was also reported that sarcoidosis patients with FEV1/FVC < 70% had increased mortality risk (odds ratio, 1.9) compared with those with FEV1/FVC ≥ 70%.20 However, clinical indices associated with airflow limitation have not been fully elucidated in
ACKNOWLEDGMENT
We thank Mr. S. Ueda, Ms. M. Aoki, Ms. M. Koshimura, and Ms. K. Tanaka for technical assistance.
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