Advances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response

Margarita K Lay; Pablo A González; Miguel A León; Pablo F Céspedes; Susan M Bueno; Claudia A Riedel; Alexis M Kalergis

doi:10.1016/j.micinf.2012.11.012

Advances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response

Microbes Infect. 2013 Mar;15(3):230-42. doi: 10.1016/j.micinf.2012.11.012. Epub 2012 Dec 12.

Authors

Margarita K Lay¹, Pablo A González, Miguel A León, Pablo F Céspedes, Susan M Bueno, Claudia A Riedel, Alexis M Kalergis

Affiliation

¹ Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda 340, Santiago E-8331010, Chile.

PMID: 23246463
DOI: 10.1016/j.micinf.2012.11.012

Abstract

This article reviews aspects of respiratory syncytial virus (RSV) infection in airway epithelial cells (AECs), including cytopathogenesis, entry, replication and the induction of immune response to the virus, including a new role for thymic stromal lymphopoietin in RSV immunopathology.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cytokines / immunology
Epithelial Cells / immunology
Epithelial Cells / pathology
Epithelial Cells / virology
Host-Pathogen Interactions / immunology
Humans
Respiratory Mucosa / immunology
Respiratory Mucosa / pathology
Respiratory Mucosa / virology
Respiratory Syncytial Virus Infections / immunology*
Respiratory Syncytial Virus Infections / pathology
Respiratory Syncytial Virus Infections / virology
Respiratory Syncytial Viruses / physiology*
Thymic Stromal Lymphopoietin
Virus Internalization
Virus Replication

Substances

Cytokines
Thymic Stromal Lymphopoietin