Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex

Alexander Moshensky; Mulong Du; John Shin; Ira Advani; Deepti Gunge; Denzil Mathew; Rita Alkolla; Ashley Du; Christian Javier; Lauren Ma; Albert Tran; Nicholas Nguyen; Jarod Olay; Sedtavut Nilaad; Jeffrey Ding; Mahan Najhawan; Jeramie D Watrous; Christine M Bojanowksi; Mohit Jain; David C Christiani; Laura E Crotty Alexander

doi:10.1183/23120541.00229-2021

Vaping-induced metabolomic signatures in the circulation of mice are driven by device type, e-liquid, exposure duration and sex

ERJ Open Res. 2021 Jul 12;7(3):00229-2021. doi: 10.1183/23120541.00229-2021. eCollection 2021 Jul.

Authors

Alexander Moshensky^{1

2}, Mulong Du³, John Shin^{1

2}, Ira Advani^{1

2}, Deepti Gunge^{1

2}, Denzil Mathew^{1

2}, Rita Alkolla^{1

2}, Ashley Du^{1

2}, Christian Javier^{1

2}, Lauren Ma^{1

2}, Albert Tran^{1

2}, Nicholas Nguyen^{1

2}, Jarod Olay^{1

2}, Sedtavut Nilaad^{1

2}, Jeffrey Ding⁴, Mahan Najhawan⁴, Jeramie D Watrous⁴, Christine M Bojanowksi^{1

2}, Mohit Jain⁴, David C Christiani^{3

5}, Laura E Crotty Alexander^{1

2}

Affiliations

¹ Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, USA.
² Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA.
³ Dept of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁴ Depts of Medicine and Pharmacology, UCSD, La Jolla, CA, USA.
⁵ Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Abstract

Each type of vaping device (vape pen, box Mod and JUUL), as well as nicotine and flavourings, induces a disparate metabolite profile or signature, such that each device and liquid is likely to lead to its own set of health effects https://bit.ly/3eExKzi.

Abstract

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