User profiles for A. John Simpson
John SimpsonProfessor of Respiratory Medicine, Newcastle University Verified email at ncl.ac.uk Cited by 9481 |
[HTML][HTML] Single-cell multi-omics analysis of the immune response in COVID-19
…, J Bacardit, HW King, AJ Rostron, AJ Simpson… - Nature medicine, 2021 - nature.com
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
Ly6Chi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis
…, C Haslett, SE Howie, AJ Simpson… - American journal of …, 2011 - atsjournals.org
… John Simpson … John Simpson … Tiemessen MM, Jagger AL, Evans HG, van Herwijnen
MJ, John S, Taams LS. CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of …
MJ, John S, Taams LS. CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of …
Regulation of transforming growth factor-β1–driven lung fibrosis by galectin-3
…, UJ Nilsson, T Delaine, AJ Simpson… - American journal of …, 2012 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar
epithelial injury with differentiation of epithelial cells and fibroblasts into matrix-secreting …
epithelial injury with differentiation of epithelial cells and fibroblasts into matrix-secreting …
Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus
…, RA Cartwright, AJ Simpson… - Proceedings of the …, 2009 - National Acad Sciences
The impact of globalization on the emergence and spread of pathogens is an important
veterinary and public health issue. Staphylococcus aureus is a notorious human pathogen …
veterinary and public health issue. Staphylococcus aureus is a notorious human pathogen …
The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium
…, C Haslett, JRW Govan, AJ Simpson… - American journal of …, 2010 - atsjournals.org
Cationic host defense peptides are key, evolutionarily conserved components of the innate
immune system. The human cathelicidin LL-37 is an important cationic host defense peptide …
immune system. The human cathelicidin LL-37 is an important cationic host defense peptide …
Residual lung abnormalities after COVID-19 hospitalization: interim analysis of the UKILD post–COVID-19 study
…, M Sereno, A Shikotra, AJ Simpson… - American journal of …, 2023 - atsjournals.org
Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19)
and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…
and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…
[HTML][HTML] Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
…, F Li, W Funston, IA Forrest, AJ Simpson… - European …, 2021 - Eur Respiratory Soc
Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the
pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and …
pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and …
A randomized controlled trial of nebulized gentamicin in non–cystic fibrosis bronchiectasis
…, JRW Govan, CJ Doherty, AJ Simpson… - American journal of …, 2011 - atsjournals.org
Rationale: Bronchiectasis is a chronic debilitating disease with few evidence-based long-term
treatments. Objectives: A randomized controlled trial assessing the efficacy of nebulized …
treatments. Objectives: A randomized controlled trial assessing the efficacy of nebulized …
Respiratory complications of organophosphorus nerve agent and insecticide poisoning. Implications for respiratory and critical care
EJ Hulse, JOJ Davies, AJ Simpson… - American journal of …, 2014 - atsjournals.org
Organophosphorus (OP) compound poisoning is a major global public health problem. Acute
OP insecticide self-poisoning kills over 200,000 people every year, the majority from self-…
OP insecticide self-poisoning kills over 200,000 people every year, the majority from self-…
The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system
…, C Cosseau, C Haslett, AJ Simpson… - Journal of leukocyte …, 2006 - academic.oup.com
The human cathelicidin LL-37 is a cationic host defense peptide (antimicrobial peptide)
expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated under …
expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated under …