Cap-dependent ribosomal scanning occurs on the majority of cellular 5′ UTRs. This process
is severely hampered on long 5′ UTRs, containing AUGs and secondary structure. These …

Background The investigation of treatment mechanisms in randomized controlled trials has
considerable clinical and theoretical relevance. Despite the empirical support for the effect of …

Background Antibiotic use and concomitant resistance are increasing. Literature reviews do
not unambiguously indicate which interventions are most effective in improving antibiotic …

Lithoprobe deep seismic reflection data from the northwestern Canadian Shield provide
images of structures to the base of the lithosphere between the Archean Slave Province on the …

Mutant p53 (mtp53) proteins can exert cancer-promoting gain-of-function activities. We
report a mechanism by which mtp53 suppresses both cell-autonomous and non-cell-autonomous …

Background High-volume prescribing of antibiotics in primary care is a major driver of
antibiotic resistance. Education of physicians and patients can lower prescribing levels, but it …

Adhesion is an important initial step during bacterial colonization of the intestinal mucosa.
However, mutations in the Salmonella typhimurium fimbrial operons lpf, pef, orfim only …

Background. Numerous studies suggest overprescribing of antibiotics for respiratory tract
indications (RTIs), without really authenticating inappropriate prescription; the strict criteria of …

Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes.
We report here that differentiated DCs can also travel from the periphery into the blood. …

Background Primary care has a crucial role in responding to the COVID-19 pandemic as the
first point of patient care and gatekeeper to secondary care. Qualitative studies exploring …