Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy

G Flores, K Dastmalchi, SB Wu, K Whalen, AJ Dabo… - Food Chemistry, 2013 - Elsevier
The potential therapeutic effects of Costa Rican guava (Psidium friedrichsthalianum) extracts
for chronic obstructive pulmonary disease were examined. The ethyl acetate fraction …

[HTML][HTML] TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease

P Geraghty, AJ Dabo, J D'Armiento - Journal of Biological Chemistry, 2011 - ASBMB
Cigarette smoke is the major risk factor associated with the development of chronic
obstructive pulmonary disease and alters expression of proteolytic enzymes that contribute to …

Cigarette smoke components induce matrix metalloproteinase-1 in aortic endothelial cells through inhibition of mTOR signaling

V Lemaître, AJ Dabo, J D'Armiento - Toxicological Sciences, 2011 - academic.oup.com
Smoking is a major risk factor for heart disease, but the molecular effects of cigarette smoke
on vascular cells are poorly understood. In this study, we demonstrate that matrix …

[HTML][HTML] Respiratory syncytial virus infections enhance cigarette smoke induced COPD in mice

RF Foronjy, AJ Dabo, CC Taggart, S Weldon… - PloS one, 2014 - journals.plos.org
Respiratory syncytial viral (RSV) infections are a frequent cause of chronic obstructive
pulmonary disease (COPD) exacerbations, which are a major factor in disease progression and …

Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment

G Flores, K Dastmalchi, S Paulino, K Whalen, AJ Dabo… - Food Chemistry, 2012 - Elsevier
Nine anthocyanins (1–9) from the edible fruits of Eugenia brasiliensis were identified by
HPLC-PDA and LC–MS, and seven of these are described for the first time in this Brazilian fruit. …

[HTML][HTML] Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection

RF Foronjy, AJ Dabo, N Cummins, P Geraghty - BMC immunology, 2014 - Springer
Background Respiratory syncytial virus (RSV) infects the lung epithelium where it stimulates
the production of numerous host cytokines that are associated with disease burden and …

[HTML][HTML] Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD)

…, BK Kumley, E Area-Gomez, Y Xu, AJ Dabo… - PloS one, 2020 - journals.plos.org
Smoke exposure is known to decrease total pulmonary surfactant and alter its composition,
but the role of surfactant in chronic obstructive pulmonary disease (COPD) remains unknown…

Protein phosphatase 2A reduces cigarette smoke–induced cathepsin S and loss of lung function

…, J Poon, RF Foronjy, M Ohlmeyer, AJ Dabo… - American Journal of …, 2019 - atsjournals.org
Rationale: CTSS (cathepsin S) is a cysteine protease that is observed at higher concentrations
in BAL fluid and plasma of subjects with chronic obstructive pulmonary disease (COPD). …

[HTML][HTML] STAT3 modulates cigarette smoke-induced inflammation and protease expression

…, AE Wyman, I Garcia-Arcos, AJ Dabo… - Frontiers in …, 2013 - frontiersin.org
Signal transducer and activator of transcription-3 (STAT3) regulates inflammation, apoptosis,
and protease expression, which are critical processes associated with airway injury and …

Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii

G Flores, K Dastmalchi, AJ Dabo, K Whalen… - Food Chemistry, 2012 - Elsevier
Four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), were
isolated from the neotropical blueberry of Anthopterus wardii, a so-called “superfruit”, using …