Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ

…, Q Chen, T Takeuchi, A Mitani… - American Journal …, 2008 - journals.physiology.org
TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain
containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes-…

Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice

A Mitani, T Nagase, K Fukuchi, H Aburatani… - American journal of …, 2009 - atsjournals.org
Rationale: Transcriptional coactivator with PDZ-binding motif (TAZ) is assumed to act as a
coactivator of several transcription factors including smad2/3. In the lung, surfactant protein C (…

[HTML][HTML] TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

…, H Takeshima, K Makita, N Miyashita, A Mitani… - Scientific reports, 2017 - nature.com
Transcriptional coactivator with PDZ-binding motif (TAZ) regulates a variety of biological
processes. Nuclear translocation and activation of TAZ are regulated by multiple mechanisms, …

Restoration of corticosteroid sensitivity in chronic obstructive pulmonary disease by inhibition of mammalian target of rapamycin

A Mitani, K Ito, C Vuppusetty, PJ Barnes… - American journal of …, 2016 - atsjournals.org
Rationale: Corticosteroid resistance is a major barrier to the effective treatment of chronic
obstructive pulmonary disease (COPD). Several molecular mechanisms have been proposed, …

Epithelial expression of YAP and TAZ is sequentially required in lung development

H Isago, A Mitani, Y Mikami, M Horie… - American Journal of …, 2020 - atsjournals.org
TAZ (transcriptional coactivator with PDZ-binding motif) and YAP (Yes-associated protein)
are key molecules of the Hippo pathway. Recent studies revealed that these molecules are …

[HTML][HTML] Putative bidirectionality of chronic obstructive pulmonary disease and periodontal disease: A review of the literature

H Tamiya, A Mitani, M Abe, T Nagase - Journal of Clinical Medicine, 2023 - mdpi.com
The prevalence of chronic obstructive pulmonary disease (COPD) is increasing worldwide
and is currently the third leading cause of death globally. The long-term inhalation of toxic …

Exosomal microRNA expression profiling in patients with lung adenocarcinoma-associated malignant pleural effusion

H Tamiya, A Mitani, A Saito, T Ishimori… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Cytological analysis for diagnosing malignant pleural effusion associated
with lung adenocarcinoma (Ad-MPE) shows limited sensitivity and novel diagnostic …

Active mTOR in lung epithelium promotes epithelial–mesenchymal transition and enhances lung fibrosis

M Saito, A Mitani, T Ishimori, N Miyashita… - American Journal of …, 2020 - atsjournals.org
The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic
pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/…

[HTML][HTML] Large gender gap in oral hygiene behavior and its impact on gingival health in late adolescence

M Abe, A Mitani, K Hoshi, S Yanagimoto - International Journal of …, 2020 - mdpi.com
Background: Epidemiologic studies provide broad-based evidence that males are at greater
risk of severe periodontal diseases than females. Our recent findings further revealed that …

Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease

A Mitani, A Azam, C Vuppusetty, K Ito… - Experimental Lung …, 2017 - Taylor & Francis
Corticosteroid resistance is a major barrier to the effective treatment of chronic obstructive
pulmonary disease (COPD). Oxidative stress from cigarette smoke and chronic inflammation is …