Mesenchymal cells are an essential cell type because of their role in tissue support, their
multilineage differentiation capacities and their potential clinical applications. They play a …

Airway–liquid interface cultures of primary epithelial cells and of induced pluripotent stem-cell-derived
airway epithelial cells (ALI and iALI, respectively) are physiologically relevant …

Background The application of CRISPR/Cas9 technology in human induced pluripotent stem
cells (hiPSC) holds tremendous potential for basic research and cell-based gene therapy. …

Chronic obstructive pulmonary disease (COPD) is a common and preventable airway
disease causing significant worldwide mortality and morbidity. Lifetime exposure to tobacco …

Recent advances in genome engineering based on the CRISPR/Cas9 technology have
revolutionized our ability to manipulate genomic DNA. Its use in human pluripotent stem cells (…

Evidence highlights the concept of multiple trajectories leading to COPD. Early-life events (ie,
in utero lung development) may influence the maximally attained lung function and …

Severe respiratory diseases including asthma need new treatments to prevent severe
clinical features in a number of patients. New models are necessary. We constructed an …

La bronchopneumopathie chronique obstructive (BPCO) est la troisième cause de mortalité
dans le monde, causant plus de 3, 2 millions de décès en 2017. Le tabagisme est la …

Le projet vise à obtenir un modèle d’épithélium bronchique innervé permettant l’étude de
différentes maladies respiratoires comme la BPCO ou encore l’asthme sévère en utilisant des …

Airway-liquid interface cultures of primary epithelial cells and of induced pluripotent stem
cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant …