User profiles for Amy Tatham
 | Amy TathamAerogen Verified email at aerogen.com Cited by 900 |
[HTML][HTML] Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the …
MJ Crabtree, AL Tatham, AB Hale, NJ Alp… - Journal of Biological …, 2009 - ASBMB
Tetrahyrobiopterin (BH4) is a required cofactor for the synthesis of nitric oxide by endothelial
nitric-oxide synthase (eNOS), and BH4 bioavailability within the endothelium is a critical …
nitric-oxide synthase (eNOS), and BH4 bioavailability within the endothelium is a critical …
[HTML][HTML] Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox …
MJ Crabtree, AL Tatham, Y Al-Wakeel, N Warrick… - Journal of Biological …, 2009 - ASBMB
Tetrahydrobiopterin (BH4) is a critical determinant of endothelial nitric-oxide synthase (eNOS)
activity. In the absence of BH4, eNOS becomes "uncoupled" and generates superoxide …
activity. In the absence of BH4, eNOS becomes "uncoupled" and generates superoxide …
Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic …
Vascular disease states are associated with endothelial dysfunction and increased
production of reactive oxygen species (ROS) derived from vascular NADPH oxidases in both …
production of reactive oxygen species (ROS) derived from vascular NADPH oxidases in both …
Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE−/− mice
…, JK Bendall, MJ Crabtree, AL Tatham… - Cardiovascular …, 2012 - academic.oup.com
Aims Vascular disease states are associated with endothelial dysfunction and increased
production of reactive oxygen species derived from NADPH oxidases. However, it remains …
production of reactive oxygen species derived from NADPH oxidases. However, it remains …
[HTML][HTML] GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback …
AL Tatham, MJ Crabtree, N Warrick, S Cai… - Journal of biological …, 2009 - ASBMB
GTP cyclohydrolase I (GTPCH) is a key enzyme in the synthesis of tetrahydrobiopterin (BH4),
a required cofactor for nitricoxide synthases and aromatic amino acid hydroxylases. …
a required cofactor for nitricoxide synthases and aromatic amino acid hydroxylases. …
CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis
…, E McNeill, M Papaspyridonos, AL Tatham… - Circulation, 2008 - Am Heart Assoc
Background— Vascular injury results in loss of endothelial nitric oxide (NO), production of
reactive oxygen species (ROS), and the initiation of an inflammatory response. Both NO and …
reactive oxygen species (ROS), and the initiation of an inflammatory response. Both NO and …
Measurement of the size and charge distribution of sodium chloride particles generated by an Aeroneb Pro® pharmaceutical nebulizer
…, C Duffy, R MacLoughlin, A Tatham… - European Journal of …, 2014 - degruyter.com
The charge distribution of aerosol is an important factor for accurate prediction of aerosol
behavior as it influences particle transport, settling, deposition, and coagulation. In the …
behavior as it influences particle transport, settling, deposition, and coagulation. In the …
Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
Aims Clinical markers of cardiac autonomic function, such as heart rate and response to
exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required …
exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required …
Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: Studies in endothelial-targeted Nox2 transgenic …
Vascular disease states are associated with endothelial dysfunction and increased
production of reactive oxygen species (ROS) derived from vascular NADPH oxidases in both …
production of reactive oxygen species (ROS) derived from vascular NADPH oxidases in both …
Evaluation of aerosol delivery during High Flow Nasal Therapy in spontaneously breathing adult and paediatric patient models
…, EF Fernández, M Joyce, G Bennett, A Tatham… - researchgate.net
RESULTS Nebuliser type had an impact on the efficiency of aerosol delivery to a patient
during HFNT. A paired t-test analysis was carried out to determine significance (p< 0.05). The …
during HFNT. A paired t-test analysis was carried out to determine significance (p< 0.05). The …