[HTML][HTML] Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts

…, JM Oldham, B Ley, CT Lee, AL Linderholm… - Nature …, 2023 - nature.com
Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated
the association of leukocyte telomere length (LTL) with chronological age and mortality …

Identification of Genes Affecting Hydrogen Sulfide Formation in Saccharomyces cerevisiae

AL Linderholm, CL Findleton, G Kumar… - Applied and …, 2008 - Am Soc Microbiol
A screen of the Saccharomyces cerevisiae deletion strain set was performed to identify genes
affecting hydrogen sulfide (H 2 S) production. Mutants were screened using two assays: …

Proteomic biomarkers of progressive fibrosing interstitial lung disease: a multicentre cohort analysis

WS Bowman, CA Newton, AL Linderholm… - The Lancet …, 2022 - thelancet.com
Background Progressive fibrosing interstitial lung disease (ILD) is characterised by
parenchymal scar formation, leading to high morbidity and mortality. The ability to predict this …

[HTML][HTML] Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study

…, Y Zhang, FJ Martinez, AL Linderholm… - The Lancet …, 2023 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease characterised by
progressive scarring leading to alveolar stiffness, reduced lung capacity, and impeded gas …

Reversal of TGFβ1-driven profibrotic state in patients with pulmonary fibrosis

…, E Foster, JM Oldham, AL Linderholm… - … England Journal of …, 2020 - Mass Medical Soc
EGCG and Pulmonary Fibrosis Nine patients who were scheduled to undergo lung biopsy
for pulmonary fibrosis were given epigallocatechin gallate (EGCG) for 2 weeks. Levels of …

Volatile emanations from in vitro airway cells infected with human rhinovirus

M Schivo, AA Aksenov, AL Linderholm… - Journal of breath …, 2014 - iopscience.iop.org
Respiratory viral infections such as human rhinovirus (HRV) can lead to substantial morbidity
and mortality, especially in people with underlying lung diseases such as asthma and …

Leukocyte telomere length and mycophenolate therapy in chronic hypersensitivity pneumonitis

…, E Vittinghoff, AL Linderholm… - European …, 2021 - Eur Respiratory Soc
Recent prospective clinical trials have shown antifibrotic therapies slow lung function
decline in patients with idiopathic pulmonary fibrosis (IPF) [1, 2] and progressive fibrosing …

[HTML][HTML] Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease

…, R Strykowski, AL Linderholm… - European …, 2023 - Eur Respiratory Soc
Background Studies suggest a harmful pharmacogenomic interaction exists between short
leukocyte telomere length (LTL) and immunosuppressants in idiopathic pulmonary fibrosis (…

Idiopathic pulmonary fibrosis is associated with common genetic variants and limited rare variants

…, JA Kropski, D Lederer, AL Linderholm… - American journal of …, 2023 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare, irreversible, and progressive
disease of the lungs. Common genetic variants, in addition to nongenetic factors, have been …

PCSK6 and survival in idiopathic pulmonary fibrosis

…, JV Pugashetti, AL Linderholm… - American Journal of …, 2023 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by
limited treatment options and high mortality. A better understanding of the molecular drivers of …