User profiles for Ashley I Heinson
Ashley I HeinsonUniversity of Southampton Verified email at btconnect.com Cited by 201 |
The promise of reverse vaccinology
AI Heinson, CH Woelk, ML Newell - International health, 2015 - academic.oup.com
Reverse vaccinology (RV) is a computational approach that aims to identify putative vaccine
candidates in the protein coding genome (proteome) of pathogens. RV has primarily been …
candidates in the protein coding genome (proteome) of pathogens. RV has primarily been …
[HTML][HTML] Enhancing the biological relevance of machine learning classifiers for reverse vaccinology
AI Heinson, Y Gunawardana, B Moesker… - International journal of …, 2017 - mdpi.com
… novel bacterial protective proteins; Ashley I. Heinson, completed the computational work
in this paper; Elena Vataga and Yawwani Gunawardana contributed analysis tools; Ashley I. …
in this paper; Elena Vataga and Yawwani Gunawardana contributed analysis tools; Ashley I. …
[HTML][HTML] Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD
…, HW Clark, A Freeman, AI Heinson… - ERJ Open …, 2023 - Eur Respiratory Soc
Rationale Pulmonary surfactant is vital for lung homeostasis as it reduces surface tension to
prevent alveolar collapse and provides essential immune-regulatory and antipathogenic …
prevent alveolar collapse and provides essential immune-regulatory and antipathogenic …
[HTML][HTML] Dual RNASeq reveals NTHi-macrophage transcriptomic changes during intracellular persistence
Nontypeable Haemophilus influenzae (NTHi) is a pathobiont which chronically colonises
the airway of individuals with chronic respiratory disease and is associated with poor clinical …
the airway of individuals with chronic respiratory disease and is associated with poor clinical …
Micro RNA targets in HIV latency: insights into novel layers of latency control
AI Heinson, J Woo, A Mukim, CH White… - AIDS research and …, 2021 - liebertpub.com
Despite the considerable progress that has been made in identifying cellular factors and
pathways that contribute to establishment and maintenance of the latent HIV reservoir, it …
pathways that contribute to establishment and maintenance of the latent HIV reservoir, it …
Classification of virologic trajectories during nucleos/tide analogue treatment of hepatitis B virus (HBV) infection
…, S Little, T Noble, KA Varnai, C Davis, AI Heinson… - medRxiv, 2023 - medrxiv.org
Background & Aims: The dynamics of HBV viral load (VL) in patients with chronic hepatitis B
(CHB) on nucleos/tide analogue (NA) treatment and its relationship with liver disease are …
(CHB) on nucleos/tide analogue (NA) treatment and its relationship with liver disease are …
[HTML][HTML] An evaluation of different classification algorithms for protein sequence-based reverse vaccinology prediction
Previous work has shown that proteins that have the potential to be vaccine candidates can
be predicted from features derived from their amino acid sequences. In this work, we make …
be predicted from features derived from their amino acid sequences. In this work, we make …
Nontypeable Haemophilus influenzae infection of pulmonary macrophages drives neutrophilic inflammation in severe asthma
Background Nontypeable Haemophilus influenzae (NTHi) is a respiratory tract pathobiont
that chronically colonizes the airways of asthma patients and is associated with severe, …
that chronically colonizes the airways of asthma patients and is associated with severe, …
[HTML][HTML] Clustering of Alzheimer's and Parkinson's disease based on genetic burden of shared molecular mechanisms
One of the visions of precision medicine has been to re-define disease taxonomies based on
molecular characteristics rather than on phenotypic evidence. However, achieving this goal …
molecular characteristics rather than on phenotypic evidence. However, achieving this goal …
Sex‐specific vitamin D effects on blood coagulation among overweight adults
…, A Manousopoulou, A Heinson… - European journal of …, 2016 - Wiley Online Library
Background Overweight adults are at increased risk for cardiovascular disease and vitamin
D deficiency, whereas an important feature to vitamin D physiology is its sex dependence. …
D deficiency, whereas an important feature to vitamin D physiology is its sex dependence. …