[PDF][PDF] Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

…, A Hamidovic, AD Hingorani, BG Nordestgaard… - Bmj, 2014 - bmj.com
Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society consensus panel statement on assessment, aetiology and …

…, E Stein, L Tokgözoğlu, BG Nordestgaard… - European heart …, 2015 - academic.oup.com
Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-adherence
and/or discontinuation, contributing to adverse cardiovascular outcomes. This …

[PDF][PDF] Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the …

…, RA Hegele, SJ Nicholls, BG Nordestgaard… - European heart …, 2020 - academic.oup.com
… This down-regulation is dependent on the G-protein-coupled oestrogen receptor and
explains why physiological levels of oestrogen reduce LDL transcytosis in arterial endothelial …

[HTML][HTML] Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

…, M Woodward, V Salomaa, BG Nordestgaard… - The Lancet, 2018 - thelancet.com
Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

Genome-wide association study identifies novel breast cancer susceptibility loci

…, G Chenevix-Trench, SE Bojesen, BG Nordestgaard… - Nature, 2007 - nature.com
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

…, N Schoof, K Humphreys, J Li, BG Nordestgaard… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

[HTML][HTML] Genetic associations with valvular calcification and aortic stenosis

…, PR Kamstrup, BG Nordestgaard… - … England Journal of …, 2013 - Mass Medical Soc
Background Limited information is available regarding genetic contributions to valvular
calcification, which is an important precursor of clinical valve disease. Methods We determined …

A common coding variant in CASP8 is associated with breast cancer risk

…, L Gibson, SE Bojesen, BG Nordestgaard… - Nature …, 2007 - nature.com
The Breast Cancer Association Consortium (BCAC) has been established to conduct combined
case-control analyses with augmented statistical power to try to confirm putative genetic …

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the …

…, JA Kuivenhoven, BG Nordestgaard… - European heart …, 2014 - academic.oup.com
Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition
characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (…

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment

…, L Masana, BG Nordestgaard… - European heart …, 2015 - academic.oup.com
Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart
disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and treated …