Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms
Endothelial dysfunction contributes to cardiovascular diseases, including hypertension,
atherosclerosis, and coronary artery disease, which are also characterized by insulin resistance. …
atherosclerosis, and coronary artery disease, which are also characterized by insulin resistance. …
Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage
Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of obesity,
metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying insulin …
metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying insulin …
Cardiovascular actions of insulin
…, M Montagnani, KK Koh, MJ Quon - Endocrine …, 2007 - academic.oup.com
Insulin has important vascular actions to stimulate production of nitric oxide from endothelium.
This leads to capillary recruitment, vasodilation, increased blood flow, and subsequent …
This leads to capillary recruitment, vasodilation, increased blood flow, and subsequent …
[HTML][HTML] Integrative analysis of 111 reference human epigenomes
The reference human genome sequence set the stage for studies of genetic variation and
its association with human disease, but epigenomic studies lack a similar reference. To …
its association with human disease, but epigenomic studies lack a similar reference. To …
Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans
…, DA Follmann, G Sullivan, MJ Quon - The Journal of …, 2000 - academic.oup.com
Insulin resistance plays an important role in the pathophysiology of diabetes and is associated
with obesity and other cardiovascular risk factors. The “gold standard” glucose clamp and …
with obesity and other cardiovascular risk factors. The “gold standard” glucose clamp and …
[HTML][HTML] FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Background Genomewide association studies can be used to identify disease-relevant
genomic regions, but interpretation of the data is challenging. The FTO region harbors the …
genomic regions, but interpretation of the data is challenging. The FTO region harbors the …
[HTML][HTML] Adiponectin stimulates production of nitric oxide in vascular endothelial cells
…, T Funahashi, I Shimomura, MJ Quon - Journal of Biological …, 2003 - ASBMB
Adiponectin is secreted by adipose cells and mimics many metabolic actions of insulin.
However, mechanisms by which adiponectin acts are poorly understood. The vascular action of …
However, mechanisms by which adiponectin acts are poorly understood. The vascular action of …
Conserved cell types with divergent features in human versus mouse cortex
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…
Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.
G Zeng, MJ Quon - The Journal of clinical investigation, 1996 - Am Soc Clin Investig
Hypertension is associated with insulin-resistant states such as diabetes and obesity. Nitric
oxide (NO) contributes to regulation of blood pressure. To gain insight into potential …
oxide (NO) contributes to regulation of blood pressure. To gain insight into potential …
[HTML][HTML] Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex
…, F Bataille, M Lefevre, D York, MJ Quon… - Journal of Biological …, 2002 - ASBMB
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus.
One mechanism mediating insulin resistance may involve the phosphorylation of serine …
One mechanism mediating insulin resistance may involve the phosphorylation of serine …