Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms

J Kim, M Montagnani, KK Koh, MJ Quon - Circulation, 2006 - Am Heart Assoc
Endothelial dysfunction contributes to cardiovascular diseases, including hypertension,
atherosclerosis, and coronary artery disease, which are also characterized by insulin resistance. …

Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage

…, S Lee, H Chen, MJ Quon - American Journal of …, 2008 - journals.physiology.org
Insulin resistance contributes to the pathophysiology of diabetes and is a hallmark of obesity,
metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying insulin …

Cardiovascular actions of insulin

…, M Montagnani, KK Koh, MJ Quon - Endocrine …, 2007 - academic.oup.com
Insulin has important vascular actions to stimulate production of nitric oxide from endothelium.
This leads to capillary recruitment, vasodilation, increased blood flow, and subsequent …

[HTML][HTML] Integrative analysis of 111 reference human epigenomes

…, JW Whitaker, MD Schultz, LD Ward, A Sarkar, G Quon… - Nature, 2015 - nature.com
The reference human genome sequence set the stage for studies of genetic variation and
its association with human disease, but epigenomic studies lack a similar reference. To …

Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans

…, DA Follmann, G Sullivan, MJ Quon - The Journal of …, 2000 - academic.oup.com
Insulin resistance plays an important role in the pathophysiology of diabetes and is associated
with obesity and other cardiovascular risk factors. The “gold standard” glucose clamp and …

[HTML][HTML] FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

…, SN Dankel, KH Kim, G Quon… - … England Journal of …, 2015 - Mass Medical Soc
Background Genomewide association studies can be used to identify disease-relevant
genomic regions, but interpretation of the data is challenging. The FTO region harbors the …

[HTML][HTML] Adiponectin stimulates production of nitric oxide in vascular endothelial cells

…, T Funahashi, I Shimomura, MJ Quon - Journal of Biological …, 2003 - ASBMB
Adiponectin is secreted by adipose cells and mimics many metabolic actions of insulin.
However, mechanisms by which adiponectin acts are poorly understood. The vascular action of …

Conserved cell types with divergent features in human versus mouse cortex

…, A Szafer, ER Thomsen, M Tieu, G Quon… - Nature, 2019 - nature.com
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells.

G Zeng, MJ Quon - The Journal of clinical investigation, 1996 - Am Soc Clin Investig
Hypertension is associated with insulin-resistant states such as diabetes and obesity. Nitric
oxide (NO) contributes to regulation of blood pressure. To gain insight into potential …

[HTML][HTML] Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex

…, F Bataille, M Lefevre, D York, MJ Quon… - Journal of Biological …, 2002 - ASBMB
Insulin resistance contributes importantly to the pathophysiology of type 2 diabetes mellitus.
One mechanism mediating insulin resistance may involve the phosphorylation of serine …