Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. …

The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

Enhanced recovery after surgery is well established in specialties such as colorectal surgery.
It is achieved through the introduction of multiple evidence-based perioperative measures …

Background Operations on structures in the chest (usually the lungs) involve cutting between
the ribs (thoracotomy). Severe post‐thoracotomy pain can result from pleural (lung lining) …

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate …

Lung cancer is the leading cause of cancer-associated mortality worldwide 1 . Here we
analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients …

Rationale Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and
intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory …

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as
a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited …

Metastatic disease is responsible for the majority of cancer-related deaths 1 . We report the
longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from …