[HTML][HTML] Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2

J Pang, X Qi, Y Luo, X Li, T Shu, B Li, M Song, Y Liu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Silicosis is a severe occupational lung disease. Current treatments for silicosis
have highly limited availability (ie, lung transplantation) or, do not effectively prolong patient …

[HTML][HTML] A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease

…, Z Li, X Qi, T Shu, B Li, D Wei, J Chen, B Li… - Ecotoxicology and …, 2020 - Elsevier
Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary
inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological …

[HTML][HTML] Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis

…, X Li, Y Liu, Y Zhou, P Yang, T Fan, Y Liu, Z Li… - … pharmaceutica Sinica B, 2022 - Elsevier
… Meiyue Song and Baicun Li constructed the experimental silicosis model. Meiyue Song,
Ying Liu, Tianhui Fan, Zhaoguo Li, and Xianmei Qi contributed to harvesting animals and lung …

Pharmacological therapy for stable chronic obstructive pulmonary disease

R Duan, B Li, T Yang - Chronic Diseases and Translational Medicine, 2023 - mednexus.org
In recent years, emphasis has shifted from preventing and treating chronic obstructive pulmonary
disease (COPD) to early prevention, early treatment, and disease stabilization, with the …

[HTML][HTML] PM2. 5 exposure promotes asthma in aged Brown-Norway rats: Implication of multiomics analysis

L Zhao, B Li, L Zhou, C Song, T Kang, Y Xu… - Ecotoxicology and …, 2023 - Elsevier
Children are disproportionately represented among those who suffer asthma, which is a kind
of chronic airway inflammation. Asthma symptoms might worsen when exposed to the air …

[HTML][HTML] Comparative transcriptome analyses reveal a transcriptional landscape of human silicosis lungs and provide potential strategies for silicosis treatment

…, Z Cao, X Qi, M Song, Y Liu, Z Li, J Zhang, B Li… - Frontiers in …, 2021 - frontiersin.org
Silicosis is a fatal occupational lung disease which currently has no effective clinical cure.
Recent studies examining the underlying mechanism of silicosis have primarily examined …

Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria

J Li, G Wang, C Hou, J Li, Y Luo, B Li - Food and agricultural …, 2019 - Taylor & Francis
Pomegranate peel polyphenols (PPPs) extracts presented anti-proliferation and apoptosis-inducing
effects in human HepG2 hepatoma cells in our previous studies. This study aimed to …

Role of IgE-FcεR1 in pathological cardiac remodeling and dysfunction

…, Y Chen, J Pang, T Shu, M Zhao, Y Tang, Z Li, B Li… - Circulation, 2021 - Am Heart Assoc
Background: Immunoglobulin E (IgE) belongs to a class of immunoglobulins involved in
immune response to specific allergens. However, the roles of IgE and IgE receptor (FcεR1) in …

[HTML][HTML] Identification of potential ATP-competitive cyclin-dependent kinase 1 inhibitors: De novo drug generation, molecular docking, and molecular dynamics …

…, Q Wu, S Liu, Y Cao, X Guo, S Yin, N Yin, B Li… - Computers in Biology …, 2023 - Elsevier
Cyclin-dependent kinases 1 (CDK1) has been identified as a potential target for the search
for new antitumor drugs. However, no clinically effective CDK1 inhibitors are now available …

[HTML][HTML] Association between long-term exposure to ambient particulate matter and pulmonary function among men and women in typical areas of south and North …

…, H He, Y Hu, J Tu, B Lin, M Lao, C Liu, B Li… - Frontiers in Public …, 2023 - frontiersin.org
Background Studies comparing the effects of different sizes and concentrations of ambient
particulate matter (PM) on pulmonary function in different regions and sexes remain sparse. …