Background With improvement in supportive therapies and the introduction of cystic fibrosis
transmembrane conductance regulator (CFTR)-modulator treatment in patients with cystic …

Background Volumetric capnography (VCap) is a simpler alternative to multiple-breath washout
(MBW) to detect ventilation inhomogeneity in patients with cystic fibrosis (CF). However, …

Rationale: The lung clearance index (LCI) is increasingly used in clinical surveillance of
patients with cystic fibrosis (CF). However, information on the natural variability of LCI are …

Background Nitrogen multiple breath washout (N2MBW) is a lung function test increasingly
used in small airway diseases. Quality criteria have not yet been globally implemented and …

Background: Lung disease starts early in life in children with cystic fibrosis (CF). Lung
clearance index (LCI) and functional matrix-pencil magnetic resonance imaging (MP-MRI) are …

Introduction: Volumetric Capnography (VCap) is a quick and easy method to assess ventilation
inhomogeneity (VI). It requires only few tidal breaths and no extensive data processing. …

Inert-gas washout (IGW) is a sensitive lung function test to measure ventilation inhomogeneity
that is attributed to mainly peripheral airways function. IGW can be performed over a …

Background: The lung clearance index (LCI) is the first lung function outcome to become
abnormal in preschool aged children with cystic fibrosis (CF). However, the clinical significance …

Background: Multiple breath washout (MBW) is increasingly used in the clinical assessment
of patients with cystic fibrosis (CF). However, guidelines for real-time quality control of MBW …

Introduction: The lung clearance index (LCI) derived from the multiple breath washout (MBW)
is a sensitive tool to detect early lung disease. However, data on inter-test reproducibility of …