[PDF][PDF] Targeting FTO suppresses cancer stem cell maintenance and immune evasion
Fat mass and obesity-associated protein (FTO), an RNA N 6 -methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis
METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6 -methyladenosine (m 6 A) in a few transcripts. Whether METTL16 methylates a …
deposition of N 6 -methyladenosine (m 6 A) in a few transcripts. Whether METTL16 methylates a …
Market design to accelerate COVID-19 vaccine supply
Each month, COVID-19 kills hundreds of thousands of people, reduces global gross
domestic product (GDP) by hundreds of billions of dollars, and generates large, accumulating …
domestic product (GDP) by hundreds of billions of dollars, and generates large, accumulating …
[PDF][PDF] R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m6A/PFKP/LDHB axis
R-2-hydroxyglutarate (R-2HG), a metabolite produced by mutant isocitrate dehydrogenases
(IDHs), was recently reported to exhibit anti-tumor activity. However, its effect on cancer …
(IDHs), was recently reported to exhibit anti-tumor activity. However, its effect on cancer …
Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates
BK Tan, M Bogdanov, J Zhao… - Proceedings of the …, 2012 - National Acad Sciences
… Tan, Mikhail Bogdanov, Jinshi Zhao … Brandon K. Tan …
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
N 6 -methyladenosine (m 6 A), the most prevalent internal modification in mammalian
mRNAs, is involved in many pathological processes. METTL16 is a recently identified m 6 A …
mRNAs, is involved in many pathological processes. METTL16 is a recently identified m 6 A …
[HTML][HTML] Akt kinase-mediated checkpoint of cGAS DNA sensing pathway
Upon DNA stimulation, cyclic GMP-AMP synthase (cGAS) synthesizes the second messenger
cyclic GMP-AMP (cGAMP) that binds to the STING, triggering antiviral interferon-β (IFN-β) …
cyclic GMP-AMP (cGAMP) that binds to the STING, triggering antiviral interferon-β (IFN-β) …
The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease
…, M Lonergan, HR Keir, CJ Fong, B Tan… - Journal of Allergy and …, 2021 - Elsevier
Background The sputum microbiome has a potential role in disease phenotyping and risk
stratification in chronic obstructive pulmonary disease (COPD), but few large longitudinal …
stratification in chronic obstructive pulmonary disease (COPD), but few large longitudinal …
Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis
L Lin, B Tan, P Pantapalangkoor, T Ho, B Baquir… - MBio, 2012 - Am Soc Microbiol
New treatments are needed for extensively drug-resistant (XDR) Gram-negative bacilli (GNB),
such as Acinetobacter baumannii . Toll-like receptor 4 (TLR4) was previously reported to …
such as Acinetobacter baumannii . Toll-like receptor 4 (TLR4) was previously reported to …
Viral and cellular N6-methyladenosine and N6,2′-O-dimethyladenosine epitranscriptomes in the KSHV life cycle
N 6 -methyladenosine (m 6 A) and N 6 ,2′-O-dimethyladenosine (m 6 Am) modifications (m
6 A/m) of messenger RNA mediate diverse cellular functions. Oncogenic Kaposi’s sarcoma-…
6 A/m) of messenger RNA mediate diverse cellular functions. Oncogenic Kaposi’s sarcoma-…