[HTML][HTML] Interactions between sleep, stress, and metabolism: From physiological to pathological conditions
C Hirotsu, S Tufik, ML Andersen - Sleep Science, 2015 - Elsevier
Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern
society. Underlying mechanisms show that stress is involved in the relationship between sleep …
society. Underlying mechanisms show that stress is involved in the relationship between sleep …
The NoSAS score for screening of sleep-disordered breathing: a derivation and validation study
H Marti-Soler, C Hirotsu, P Marques-Vidal… - The Lancet …, 2016 - thelancet.com
Background Diagnosis of sleep-disordered breathing requires overnight recordings, such
as polygraphy or polysomnography. Considering the cost and low availability of these …
as polygraphy or polysomnography. Considering the cost and low availability of these …
[HTML][HTML] Sleep loss and cytokines levels in an experimental model of psoriasis
Up to 80% of people develop a cutaneous condition closely connected to their exposure to
stressful life events. Psoriasis is a chronic recurrent inflammatory skin disorder with …
stressful life events. Psoriasis is a chronic recurrent inflammatory skin disorder with …
Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats
…, JP Machado-de-Sousa, C Hirotsu… - Journal of …, 2013 - journals.sagepub.com
Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum
of action, including effects in the sleep-wake cycle. Objective: The objective of this paper …
of action, including effects in the sleep-wake cycle. Objective: The objective of this paper …
Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice
F Hakim, Y Wang, A Carreras, C Hirotsu, J Zhang… - Sleep, 2015 - academic.oup.com
Background: Sleep fragmentation (SF) is highly prevalent and may constitute an important
contributing factor to excessive weight gain and the metabolic syndrome. Increased …
contributing factor to excessive weight gain and the metabolic syndrome. Increased …
[HTML][HTML] The interfaces between vitamin D, sleep and pain
DL de Oliveira, C Hirotsu, S Tufik… - Journal of …, 2017 - joe.bioscientifica.com
The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested
its action on different biological mechanisms, such as nociceptive sensitivity and sleep–…
its action on different biological mechanisms, such as nociceptive sensitivity and sleep–…
Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice
…, BA Neel, MJ Brady, Z Qiao, C Hirotsu… - International journal of …, 2014 - nature.com
Background: Short sleep has been implicated in higher risk of obesity in humans, and is
associated with insulin resistance. However, the effects of fragmented sleep (SF) rather than …
associated with insulin resistance. However, the effects of fragmented sleep (SF) rather than …
[HTML][HTML] Association between uric acid levels and obstructive sleep apnea syndrome in a large epidemiological sample
C Hirotsu, S Tufik, C Guindalini, DR Mazzotti… - PloS one, 2013 - journals.plos.org
Introduction Recurrent hypoxia, which is associated with obstructive sleep apnea syndrome
(OSAS), leads to an increase in the degradation of adenosine triphosphatase into xanthine, …
(OSAS), leads to an increase in the degradation of adenosine triphosphatase into xanthine, …
[HTML][HTML] Impairment of male reproductive function after sleep deprivation
TA Alvarenga, C Hirotsu, R Mazaro-Costa, S Tufik… - Fertility and sterility, 2015 - Elsevier
Objective To evaluate the influence of sleep loss on sexual behavior, hormone levels, sperm
parameters, and testis-specific gene expression in male rats. Design Experimental research…
parameters, and testis-specific gene expression in male rats. Design Experimental research…
Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period
…, F Kayali, J Zhang, C Hirotsu… - American Journal …, 2012 - journals.physiology.org
Intermittent hypoxia (IH) is a frequent occurrence in sleep and respiratory disorders. Both
human and murine studies show that IH may be implicated in metabolic dysfunction. Although …
human and murine studies show that IH may be implicated in metabolic dysfunction. Although …