[HTML][HTML] Interactions between sleep, stress, and metabolism: From physiological to pathological conditions

C Hirotsu, S Tufik, ML Andersen - Sleep Science, 2015 - Elsevier
Poor sleep quality due to sleep disorders and sleep loss is highly prevalent in the modern
society. Underlying mechanisms show that stress is involved in the relationship between sleep …

The NoSAS score for screening of sleep-disordered breathing: a derivation and validation study

H Marti-Soler, C Hirotsu, P Marques-Vidal… - The Lancet …, 2016 - thelancet.com
Background Diagnosis of sleep-disordered breathing requires overnight recordings, such
as polygraphy or polysomnography. Considering the cost and low availability of these …

[HTML][HTML] Sleep loss and cytokines levels in an experimental model of psoriasis

C Hirotsu, M Rydlewski, MS Araujo, S Tufik… - PloS one, 2012 - journals.plos.org
Up to 80% of people develop a cutaneous condition closely connected to their exposure to
stressful life events. Psoriasis is a chronic recurrent inflammatory skin disorder with …

Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats

…, JP Machado-de-Sousa, C Hirotsu… - Journal of …, 2013 - journals.sagepub.com
Cannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum
of action, including effects in the sleep-wake cycle. Objective: The objective of this paper …

Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice

F Hakim, Y Wang, A Carreras, C Hirotsu, J Zhang… - Sleep, 2015 - academic.oup.com
Background: Sleep fragmentation (SF) is highly prevalent and may constitute an important
contributing factor to excessive weight gain and the metabolic syndrome. Increased …

[HTML][HTML] The interfaces between vitamin D, sleep and pain

DL de Oliveira, C Hirotsu, S Tufik… - Journal of …, 2017 - joe.bioscientifica.com
The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested
its action on different biological mechanisms, such as nociceptive sensitivity and sleep–…

Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice

…, BA Neel, MJ Brady, Z Qiao, C Hirotsu… - International journal of …, 2014 - nature.com
Background: Short sleep has been implicated in higher risk of obesity in humans, and is
associated with insulin resistance. However, the effects of fragmented sleep (SF) rather than …

[HTML][HTML] Association between uric acid levels and obstructive sleep apnea syndrome in a large epidemiological sample

C Hirotsu, S Tufik, C Guindalini, DR Mazzotti… - PloS one, 2013 - journals.plos.org
Introduction Recurrent hypoxia, which is associated with obstructive sleep apnea syndrome
(OSAS), leads to an increase in the degradation of adenosine triphosphatase into xanthine, …

[HTML][HTML] Impairment of male reproductive function after sleep deprivation

TA Alvarenga, C Hirotsu, R Mazaro-Costa, S Tufik… - Fertility and sterility, 2015 - Elsevier
Objective To evaluate the influence of sleep loss on sexual behavior, hormone levels, sperm
parameters, and testis-specific gene expression in male rats. Design Experimental research…

Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period

…, F Kayali, J Zhang, C Hirotsu… - American Journal …, 2012 - journals.physiology.org
Intermittent hypoxia (IH) is a frequent occurrence in sleep and respiratory disorders. Both
human and murine studies show that IH may be implicated in metabolic dysfunction. Although …