Several in vitro studies have correlated dysfunction of the sphingolipid-signaling pathway
with promotion of tumor cell growth as well as progression and resistance of tumors to …

Epoxyeicosatrienoic acids (EETs) are cytochrome P450-epoxygenase-derived metabolites of
arachidonic acid that act as endogenous signaling molecules in multiple biological systems…

The endocannabinoid (eCB) system plays central roles in the regulation of food intake and
energy expenditure. Its alteration in activity contributes to the development and maintenance …

Prostaglandins (PGs) are important regulators of reproductive processes including early
embryonic development. We analyzed the most relevant PG in bovine uteri at different …

Background Infectious agents can reprogram or “train” macrophages and their progenitors
to respond more readily to subsequent insults. However, whether such an inflammatory …

Background— Pharmacological inhibition of cyclooxygenase-2 increases the risk of
myocardial infarction (MI) and stroke. Microsomal prostaglandin (PG) E 2 synthase-1 (mPGES-1), …

Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose- and therapy-limiting
side effect of widely used cytostatics that is particularly difficult to treat. Here, we …

Frankincense preparations, used in folk medicine to cure inflammatory diseases, showed
anti-inflammatory effectiveness in animal models and clinical trials. Boswellic acids (BAs) …

Execution of physiologic cell death known as apoptosis is tightly regulated and transfers
immunologically relevant information. This ensures efficient clearance of dying cells and shapes …

Resolution of acute inflammation is an active process coordinated by proresolving lipid
mediators (SPMs) such as lipoxins (LXs) and resolvins (Rvs), which are formed by the concerted …