Since March 10, 2020, the Newcastle upon Tyne Hospitals National Health Service (NHS)
Foundation Trust has been screening symptomatic health-care workers for severe acute …

NK cells have shown promise in therapy of hematological cancers, in particular against acute
myeloid leukemia. In contrast, the more NK cell-resistant acute lymphoblastic leukemia (…

Recent large national and international cohorts describe the baseline characteristics and
outcome of hospitalised patients with COVID-19, however there is limited granularity to these …

Acute graft-versus-host disease (aGvHD) is a major cause of adverse outcome in hematopoietic
stem cell transplantation (HSCT), with a high incidence (20–50%). A novel, non-invasive …

Abstract'Quick-kill'strategies in pharmaceutical research and development aim to reduce late-
stage attrition by bringing project termination decisions forward, to an earlier point in the …

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable
risk. Here we perform a meta-analysis of three genome-wide association studies, with …

Acute graft-versus-host disease (aGvHD) is the most frequent and serious complication
following hematopoietic stem cell transplantation (HSCT), with a high mortality rate. A clearer …

Background A subset of patients with severe COVID-19 develop a hyperinflammatory
syndrome, which might contribute to morbidity and mortality. This study explores a specific …

Background Ventilator-associated pneumonia (VAP) is an important diagnosis in critical
care. VAP research is complicated by the lack of agreed diagnostic criteria and reference …

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for
numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is …