User profiles for Claudie Gabillard-Lefort

Claudie Gabillard-Lefort

Institut MitoVasc, Université d'Angers
Verified email at univ-angers.fr
Cited by 238

Trikafta rescues CFTR and lowers monocyte P2X7R-induced inflammasome activation in cystic fibrosis

C Gabillard-Lefort, M Casey, AMA Glasgow… - American journal of …, 2022 - atsjournals.org
Rationale: Cystic fibrosis (CF) is caused by mutations in the CFTR (CF transmembrane
conductance regulator) gene and is characterized by sustained inflammation. ATP triggers IL-1β …

[HTML][HTML] A review of alpha-1 antitrypsin binding partners for immune regulation and potential therapeutic application

…, MR Wormald, M Casey, C Gabillard-Lefort… - International Journal of …, 2022 - mdpi.com
Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived
proteases and can modulate innate immune mechanisms through its anti-inflammatory activities …

[HTML][HTML] Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications

…, JL Torres-Castillo, RS Hagan, C Gabillard-Lefort… - …, 2022 - thelancet.com
Background Interleukin-6 (IL-6) is elevated in SARS-CoV-2 infection. IL-6 regulates acute-phase
proteins, such as alpha-1 antitrypsin (AAT), a key lung anti-protease. We investigated …

Effect of elexacaftor/tezacaftor/ivacaftor on airway and systemic inflammation in cystic fibrosis

M Casey, C Gabillard-Lefort, OF McElvaney… - Thorax, 2023 - thorax.bmj.com
Treatment with elexacaftor/tezacaftor/ivacaftor (ETI) has been shown to improve lung function
in people with cystic fibrosis (PWCF). However, its biological effects remain incompletely …

Current evidence on the effect of highly effective CFTR modulation on interleukin-8 in cystic fibrosis

M Williamson, M Casey, C Gabillard-Lefort… - Expert Review of …, 2022 - Taylor & Francis
Introduction Cystic fibrosis (CF) is a genetically inherited disease, with mortality and morbidity
associated with respiratory disease. The inflammatory response in CF is characterized by …

[HTML][HTML] P2y11 agonism prevents hypoxia/reoxygenation-and angiotensin II-induced vascular dysfunction and intimal hyperplasia development

…, A Sturza, S Chadet, C Gabillard-Lefort… - International Journal of …, 2021 - mdpi.com
Vascular dysfunction in cardiovascular diseases includes vasomotor response impairments,
endothelial cells (ECs) activation, and smooth muscle cells (SMCs) proliferation and …

In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by α1-antitrypsin

P Hawkins, T McEnery, C Gabillard-Lefort… - ERJ Open …, 2021 - Eur Respiratory Soc
Oxidative stress from innate immune cells is a driving mechanism that underlies COPD
pathogenesis. Individuals with α-1 antitrypsin (AAT) deficiency (AATD) have a dramatically …

Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in response to a chronic hypertensive environment

…, P Fontanaud, F De Nardi, C Gabillard-Lefort… - bioRxiv, 2023 - biorxiv.org
Chronic elevated blood pressure impinges on the functioning of multiple organs and therefore
harms body homeostasis. Elucidating the protective mechanisms whereby the organism …

SUPPLEMENTARY METHODOLOGY

M Casey, C Gabillard-Lefort, OF McElvaney… - Thorax, 2023 - thorax.bmj.com
A total of 45 patients presenting to Beaumont Hospital Adult CF unit were deemed eligible
for the study based on genotype and above limitations. From the initial recruitment visit, …

CFTR Modulator Therapy Rescues CFTR and Lowers P2X7R-induced Inflammasome Activation of Airway Epithelial Cells

…, C Gunaratnam, NG Mcelvaney, C Gabillard-Lefort… - 2023 - Eur Respiratory Soc
Background: Cystic Fibrosis (CF) is caused by mutations in the CF transmembrane conductance
regulator (CFTR) gene and is characterized by sustained inflammation. Elexacaftor/…