End-stage organ failure is a key challenge for the medical community because of the ageing
population and the severe shortage of suitable donor organs available. Equally, injuries to …

Background Since 2000, the scale-up of malaria control interventions has substantially
reduced morbidity and mortality caused by the disease globally, fuelling bold aims for disease …

10.7554/eLife.04395.001 Ebola virus disease (EVD) is a complex zoonosis that is highly
virulent in humans. The largest recorded outbreak of EVD is ongoing in West Africa, outside of …

Mesenchymal stromal cells (MSCs) as a pharmaceutical for ailments characterized by pathogenic
autoimmune, alloimmune and inflammatory processes now cover the spectrum of early…

The development of methods to achieve efficient reprogramming of human cells while avoiding
the permanent presence of reprogramming transgenes represents a critical step toward …

Background COPD is a devastating disease affecting millions worldwide. As disease pathogenesis
includes both chronic pulmonary and systemic inflammation, antiinflammatory effects …

Two populations of Nkx2-1 + progenitors in the developing foregut endoderm give rise to the
entire postnatal lung and thyroid epithelium, but little is known about these cells because …

Over the course of the first year of life, infants develop from being generalized listeners, capable
of discriminating both native and non‐native speech contrasts, into specialized listeners …

Small extracellular vesicles (sEVs) from mesenchymal stromal/stem cells (MSCs) are transiting
rapidly towards clinical applications. However, discrepancies and controversies about …

The University of Vermont College of Medicine and the Vermont Lung Center, with support
of the National Heart, Lung, and Blood Institute (NHLBI), the Alpha-1 Foundation, the …