User profiles for Daniel Navajas

Daniel Navajas

Professor Emeritus of Physiology, School of Medicine and Health Sciences. University of …
Verified email at ub.edu
Cited by 51386

Universal physical responses to stretch in the living cell

X Trepat, L Deng, SS An, D Navajas, DJ Tschumperlin… - Nature, 2007 - nature.com
With every beat of the heart, inflation of the lung or peristalsis of the gut, cell types of diverse
function are subjected to substantial stretch. Stretch is a potent stimulus for growth, …

Scaling the microrheology of living cells

…, GN Maksym, JP Butler, M Glogauer, D Navajas… - Physical review …, 2001 - APS
We report a scaling law that governs both the elastic and frictional properties of a wide
variety of living cell types, over a wide range of time scales and under a variety of biological …

[PDF][PDF] Force triggers YAP nuclear entry by regulating transport across nuclear pores

…, AL Le Roux, CM Shanahan, X Trepat, D Navajas… - Cell, 2017 - cell.com
YAP is a mechanosensitive transcriptional activator with a critical role in cancer, regeneration,
and organ size control. Here, we show that force applied to the nucleus directly drives …

[HTML][HTML] Microrheology of human lung epithelial cells measured by atomic force microscopy

…, M Grabulosa, X Trepat, B Fabry, R Farré, D Navajas - Biophysical journal, 2003 - cell.com
Lung epithelial cells are subjected to large cyclic forces from breathing. However, their response
to dynamic stresses is poorly defined. We measured the complex shear modulus (G * (ω…

Collective cell durotaxis emerges from long-range intercellular force transmission

…, A Elosegui-Artola, A Labernadie, L Valon, D Navajas… - Science, 2016 - science.org
The ability of cells to follow gradients of extracellular matrix stiffness—durotaxis—has been
implicated in development, fibrosis, and cancer. Here, we found multicellular clusters that …

Probing mechanical properties of living cells by atomic force microscopy with blunted pyramidal cantilever tips

…, N Gavara, R Farré, M Rotger, D Navajas - Physical Review E, 2005 - APS
Atomic force microscopy (AFM) allows the acquisition of high-resolution images and the
measurement of mechanical properties of living cells under physiological conditions. AFM …

Time scale and other invariants of integrative mechanical behavior in living cells

…, GN Maksym, JP Butler, M Glogauer, D Navajas… - Physical Review E, 2003 - APS
In dealing with systems as complex as the cytoskeleton, we need organizing principles or,
short of that, an empirical framework into which these systems fit. We report here unexpected …

Effectiveness of CPAP treatment in daytime function in sleep apnea syndrome: a randomized controlled study with an optimized placebo

…, R FARRÉ, G VILAGUT, D NAVAJAS… - American Journal of …, 2001 - atsjournals.org
Application of continuous positive airway pressure (CPAP) as the standard treatment for
sleep apnea/hypopnea syndrome (SAHS) is a moot point. Studies on the effectiveness of this …

Force loading explains spatial sensing of ligands by cells

…, I Platzman, P Delcanale, L Albertazzi, D Navajas… - Nature, 2017 - nature.com
Cells can sense the density and distribution of extracellular matrix (ECM) molecules by means
of individual integrin proteins and larger, integrin-containing adhesion complexes within …