Urine lipoarabinomannan glycan in HIV-negative patients with pulmonary tuberculosis correlates with disease severity

…, N Saini, M Harpole, J Coronel, DE Kirwan… - Science translational …, 2017 - science.org
An accurate urine test for pulmonary tuberculosis (TB), affecting 9.6 million patients worldwide,
is critically needed for surveillance and treatment management. Past attempts failed to …

Dynamics of cough frequency in adults undergoing treatment for pulmonary tuberculosis

…, A Salas, E Ticona, NM Vu, DE Kirwan… - Clinical infectious …, 2017 - academic.oup.com
Background. Cough is the major determinant of tuberculosis transmission. Despite this, there
is a paucity of information regarding characteristics of cough frequency throughout the day …

Platelets regulate pulmonary inflammation and tissue destruction in tuberculosis

KA Fox, DE Kirwan, AM Whittington… - American journal of …, 2018 - atsjournals.org
Rationale: Platelets may interact with the immune system in tuberculosis (TB) to regulate
human inflammatory responses that lead to morbidity and spread of infection. Objectives: To …

[HTML][HTML] Platelet activation and the immune response to tuberculosis

DE Kirwan, DLW Chong, JS Friedland - Frontiers in Immunology, 2021 - frontiersin.org
In 2019 10 million people developed symptomatic tuberculosis (TB) disease and 1.2 million
died. In active TB the inflammatory response causes tissue destruction, which leads to both …

Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections

HM Staines, DE Kirwan, DJ Clark, ER Adams… - MedRxiv, 2020 - medrxiv.org
We report dynamics of seroconversion to SARS-CoV-2 infections detected by IgG ELISA in
177 individuals diagnosed by RT-PCR. Longitudinal analysis identifies 2-8.5% of individuals …

[HTML][HTML] IgG seroconversion and pathophysiology in severe acute respiratory syndrome coronavirus 2 infection

HM Staines, DE Kirwan, DJ Clark… - Emerging infectious …, 2021 - ncbi.nlm.nih.gov
We investigated the dynamics of seroconversion in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. During March 29–May 22, 2020, we collected serum …

[HTML][HTML] Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis

…, HM Staines, JRA Fitchett, DE Kirwan… - PLoS neglected …, 2021 - journals.plos.org
Background Individuals infected with SARS-CoV-2 develop neutralising antibodies. We
investigated the proportion of individuals with SARS-CoV-2 neutralising antibodies after …

[HTML][HTML] An acidic microenvironment in Tuberculosis increases extracellular matrix degradation by regulating macrophage inflammatory responses

…, FS Turner, F Baark, S Templeman, DE Kirwan… - PLoS …, 2023 - journals.plos.org
Mycobacterium tuberculosis (M.tb) infection causes marked tissue inflammation leading to
lung destruction and morbidity. The inflammatory extracellular microenvironment is acidic, …

Protocol for studying cough frequency in people with pulmonary tuberculosis

…, JL Cabrera, A Salas, E Ticona, DE Kirwan… - BMJ open, 2016 - bmjopen.bmj.com
Introduction Cough is a key symptom of tuberculosis (TB) as well as the main cause of
transmission. However, a recent literature review found that cough frequency (number of coughs …

[HTML][HTML] Mycobacterium tuberculosis ribosomal protein S1 (RpsA) and variants with truncated C-terminal end show absence of interaction with pyrazinoic acid

…, R Antiparra, E Toscano, H Saavedra, DE Kirwan… - Scientific reports, 2020 - nature.com
Pyrazinamide (PZA) is an antibiotic used in first- and second-line tuberculosis treatment
regimens. Approximately 50% of multidrug-resistant tuberculosis and over 90% of extensively …