[HTML][HTML] Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacologic activation of Nrf2 (NF-E2 p45-related factor 2)
…, DJ Harrison, D Kisielewski, DM Cassidy… - Cellular and molecular …, 2018 - Elsevier
Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress.
We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the …
We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the …
Trunk muscle strength is impaired multidirectionally after stroke
RW Bohannon, D Cassidy, S Walsh - Clinical rehabilitation, 1995 - journals.sagepub.com
This study was undertaken to describe and compare the forward and lateral trunk flexion
strength of 20 patients with stroke and hemiparesis and 20 matched controls. Trunk flexion …
strength of 20 patients with stroke and hemiparesis and 20 matched controls. Trunk flexion …
The post-mortem relationship between beta-hydroxybutyrate (BHB), acetone and ethanol in ketoacidosis
S Elliott, C Smith, D Cassidy - Forensic science international, 2010 - Elsevier
A reduced blood pH (ketoacidosis) from the production of β-oxidative ketone bodies as a
result of alcoholism (alcoholic ketoacidosis, AKA) or diabetes (diabetic ketoacidosis, DKA) can …
result of alcoholism (alcoholic ketoacidosis, AKA) or diabetes (diabetic ketoacidosis, DKA) can …
[HTML][HTML] Mechanistic insight into control of CFTR by AMPK
P Kongsuphol, D Cassidy, B Hieke, KJ Treharne… - Journal of Biological …, 2009 - ASBMB
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP and protein
kinase A (PKA)-regulated Cl – channel in the apical membrane of epithelial cells. The …
kinase A (PKA)-regulated Cl – channel in the apical membrane of epithelial cells. The …
[HTML][HTML] Expression of wild-type CFTR suppresses NF-κB-driven inflammatory signalling
MJ Hunter, KJ Treharne, AK Winter, DM Cassidy… - PloS one, 2010 - journals.plos.org
Background Mutation of the cystic fibrosis transmembrane-conductance regulator (CFTR)
causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion …
causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion …
Pregnancy zone protein is associated with airway infection, neutrophil extracellular trap formation, and disease severity in bronchiectasis
…, B Tan, JY Choi, TC Fardon, D Cassidy… - American journal of …, 2019 - atsjournals.org
Rationale: PZP (pregnancy zone protein) is a broad-spectrum immunosuppressive protein
believed to suppress T-cell function during pregnancy to prevent fetal rejection. It has not …
believed to suppress T-cell function during pregnancy to prevent fetal rejection. It has not …
Antimicrobial peptides, disease severity and exacerbations in bronchiectasis
O Sibila, L Perea, E Cantó, A Shoemark, D Cassidy… - Thorax, 2019 - thorax.bmj.com
Rationale Recently a frequent exacerbator phenotype has been described in bronchiectasis,
but the underlying biological mechanisms are unknown. Antimicrobial peptides (AMPs) are …
but the underlying biological mechanisms are unknown. Antimicrobial peptides (AMPs) are …
[HTML][HTML] The protective effect of SARS-CoV-2 antibodies in Scottish healthcare workers
H Abo-Leyah, S Gallant, D Cassidy… - ERJ Open …, 2021 - Eur Respiratory Soc
Background Healthcare workers (HCWs) are believed to be at increased risk of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It is not known to what extent …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It is not known to what extent …
[HTML][HTML] Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial
…, H Turton, H Richardson, D Cassidy… - The Lancet …, 2022 - thelancet.com
Background Neutrophil serine proteases are involved in the pathogenesis of COVID-19 and
increased serine protease activity has been reported in severe and fatal infection. We …
increased serine protease activity has been reported in severe and fatal infection. We …
[HTML][HTML] Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection
…, C Hughes, BJM New, D Cassidy… - European …, 2024 - Eur Respiratory Soc
Background Neutrophils are important in the pathophysiology of coronavirus disease 2019 (COVID-19),
but the molecular changes contributing to altered neutrophil phenotypes …
but the molecular changes contributing to altered neutrophil phenotypes …