Functional tissue regeneration is required for the restoration of normal organ homeostasis
after severe injury. Some organs, such as the intestine, harbour active stem cells throughout …

The human lung differs substantially from its mouse counterpart, resulting in a distinct distal
airway architecture affected by disease pathology in chronic obstructive pulmonary disease. …

Rationale: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality
after lung transplantation. Previous studies have yielded conflicting results for PGD risk …

Primary graft dysfunction (PGD) refers to the syndrome of acute lung injury early after lung
transplantation (LTx). 1 In 2005, based on the need for a reliable and valid definition with clear …

Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and
limited target organ deposition, even when NCs are targeted using affinity moieties. Here we …

Group 2 innate lymphoid cells (ILC2s) regulate tissue inflammation and repair after
activation by cell-extrinsic factors such as host-derived cytokines. However, the cell-intrinsic …

Few studies have examined the lung virome in health and disease. Outcomes of lung
transplantation are known to be influenced by several recognized respiratory viruses, but global …

Data from mouse tumor models suggest that tumor-associated monocyte/macrophage lineage
cells (MMLCs) dampen antitumor immune responses. However, given the fundamental …

Background Chronic allograft dysfunction limits the long-term success of lung transplantation.
Increasing evidence suggests nonimmune mediated injury such as due to reflux …

Lungs undergo mechanical strain during breathing, but how these biophysical forces affect
cell fate and tissue homeostasis are unclear. We show that biophysical forces through normal …