Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's
disease (HD), a neurodegenerative disorder. The mutant protein is presumed to acquire a toxic …
disease (HD), a neurodegenerative disorder. The mutant protein is presumed to acquire a toxic …
A gene network regulating lysosomal biogenesis and function
Lysosomes are organelles central to degradation and recycling processes in animal cells.
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …
Brain-derived neurotrophic factor in neurodegenerative diseases
C Zuccato, E Cattaneo - Nature Reviews Neurology, 2009 - nature.com
Abstract Changes in the levels and activities of neurotrophic factors, such as brain-derived
neurotrophic factor (BDNF), have been described in a number of neurodegenerative disorders…
neurotrophic factor (BDNF), have been described in a number of neurodegenerative disorders…
Molecular mechanisms and potential therapeutical targets in Huntington's disease
C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion
in the gene encoding for huntingtin protein. A lot has been learned about this disease …
in the gene encoding for huntingtin protein. A lot has been learned about this disease …
Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor
E Cattaneo, R McKay - Nature, 1990 - nature.com
NERVE growth factor plays an important part in neuron–target interactions in the late
embryonic and adult brain. We now report that this growth factor controls the proliferation of …
embryonic and adult brain. We now report that this growth factor controls the proliferation of …
SUMO modification of Huntingtin and Huntington's disease pathology
…, N Slepko, K Illes, T Lukacsovich, YZ Zhu, E Cattaneo… - Science, 2004 - science.org
Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein,
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …
Normal huntingtin function: an alternative approach to Huntington's disease
E Cattaneo, C Zuccato, M Tartari - Nature Reviews Neuroscience, 2005 - nature.com
Several neurological diseases are characterized by the altered activity of one or a few
ubiquitously expressed cell proteins, but it is not known how these normal proteins turn into …
ubiquitously expressed cell proteins, but it is not known how these normal proteins turn into …
[HTML][HTML] EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
…, J Ragaz, A Cahn, L Linger, H Ozdag, E Cattaneo… - Cell, 2003 - cell.com
The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated
in DNA repair and transcriptional regulation. Here we identify a protein, EMSY, which …
in DNA repair and transcriptional regulation. Here we identify a protein, EMSY, which …
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Huntingtin protein is mutated in Huntington disease 1 . We previously reported that wild-type
but not mutant huntingtin stimulates transcription of the gene encoding brain-derived …
but not mutant huntingtin stimulates transcription of the gene encoding brain-derived …
[HTML][HTML] Niche-independent symmetrical self-renewal of a mammalian tissue stem cell
Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical
divisions. In vivo, however, stem cells are generally thought to depend on specialised …
divisions. In vivo, however, stem cells are generally thought to depend on specialised …