Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

…, MR Hayden, T Timmusk, S Sipione, E Cattaneo - Science, 2001 - science.org
Huntingtin is a 350-kilodalton protein of unknown function that is mutated in Huntington's
disease (HD), a neurodegenerative disorder. The mutant protein is presumed to acquire a toxic …

A gene network regulating lysosomal biogenesis and function

…, RS Polishchuk, S Banfi, G Parenti, E Cattaneo… - Science, 2009 - science.org
Lysosomes are organelles central to degradation and recycling processes in animal cells.
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …

Brain-derived neurotrophic factor in neurodegenerative diseases

C Zuccato, E Cattaneo - Nature Reviews Neurology, 2009 - nature.com
Abstract Changes in the levels and activities of neurotrophic factors, such as brain-derived
neurotrophic factor (BDNF), have been described in a number of neurodegenerative disorders…

Molecular mechanisms and potential therapeutical targets in Huntington's disease

C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion
in the gene encoding for huntingtin protein. A lot has been learned about this disease …

Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor

E Cattaneo, R McKay - Nature, 1990 - nature.com
NERVE growth factor plays an important part in neuron–target interactions in the late
embryonic and adult brain. We now report that this growth factor controls the proliferation of …

SUMO modification of Huntingtin and Huntington's disease pathology

…, N Slepko, K Illes, T Lukacsovich, YZ Zhu, E Cattaneo… - Science, 2004 - science.org
Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein,
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …

Normal huntingtin function: an alternative approach to Huntington's disease

E Cattaneo, C Zuccato, M Tartari - Nature Reviews Neuroscience, 2005 - nature.com
Several neurological diseases are characterized by the altered activity of one or a few
ubiquitously expressed cell proteins, but it is not known how these normal proteins turn into …

[HTML][HTML] EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

…, J Ragaz, A Cahn, L Linger, H Ozdag, E Cattaneo… - Cell, 2003 - cell.com
The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated
in DNA repair and transcriptional regulation. Here we identify a protein, EMSY, which …

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

…, MR Hayden, T Timmusk, D Rigamonti, E Cattaneo - Nature …, 2003 - nature.com
Huntingtin protein is mutated in Huntington disease 1 . We previously reported that wild-type
but not mutant huntingtin stimulates transcription of the gene encoding brain-derived …

[HTML][HTML] Niche-independent symmetrical self-renewal of a mammalian tissue stem cell

…, G Biella, Y Sun, S Sanzone, QL Ying, E Cattaneo… - PLoS …, 2005 - journals.plos.org
Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical
divisions. In vivo, however, stem cells are generally thought to depend on specialised …