User profiles for Elizabeth Perez
Elizabeth PerezHarvard University Verified email at g.harvard.edu Cited by 6119 |
[PDF][PDF] An integrative model of cellular states, plasticity, and genetics for glioblastoma
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable
and poorly understood tumor, but their precise characterization remains challenging. Here, …
and poorly understood tumor, but their precise characterization remains challenging. Here, …
[PDF][PDF] Cohesin loss eliminates all loop domains
…, SC Huang, BG St Hilaire, JM Engreitz, EM Perez… - Cell, 2017 - cell.com
The human genome folds to create thousands of intervals, called "contact domains," that
exhibit enhanced contact frequency within themselves. "Loop domains" form because of …
exhibit enhanced contact frequency within themselves. "Loop domains" form because of …
Local regulation of gene expression by lncRNA promoters, transcription and splicing
Mammalian genomes are pervasively transcribed 1 , 2 to produce thousands of long non-coding
RNAs (lncRNAs) 3 , 4 . A few of these lncRNAs have been shown to recruit regulatory …
RNAs (lncRNAs) 3 , 4 . A few of these lncRNAs have been shown to recruit regulatory …
Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
Enhancer elements in the human genome control how genes are expressed in specific cell
types and harbor thousands of genetic variants that influence risk for common diseases 1 , 2 , …
types and harbor thousands of genetic variants that influence risk for common diseases 1 , 2 , …
Systematic mapping of functional enhancer–promoter connections with CRISPR interference
Gene expression in mammals is regulated by noncoding elements that can affect physiology
and disease, yet the functions and target genes of most noncoding elements remain …
and disease, yet the functions and target genes of most noncoding elements remain …
Isolation and characterization of mineral phosphate-solubilizing bacteria naturally colonizing a limonitic crust in the south-eastern Venezuelan region
E Perez, M Sulbaran, MM Ball, LA Yarzabal - Soil Biology and Biochemistry, 2007 - Elsevier
With the aim to explore the possible role of mineral phosphate-solubilizing bacteria (PSB) in
phosphorus (P) cycling in iron-rich, acidic soils, we conducted a survey of PSB naturally …
phosphorus (P) cycling in iron-rich, acidic soils, we conducted a survey of PSB naturally …
[PDF][PDF] Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
T cells are critical effectors of cancer immunotherapies, but little is known about their gene
expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing (RNA-…
expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing (RNA-…
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function
G Notarangelo, JB Spinelli, EM Perez, GJ Baker… - Science, 2022 - science.org
Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …
[PDF][PDF] The proteomic landscape of triple-negative breast cancer
Triple-negative breast cancer is a heterogeneous disease characterized by poor clinical
outcomes and a shortage of targeted treatment options. To discover molecular features of triple-…
outcomes and a shortage of targeted treatment options. To discover molecular features of triple-…
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic
determinants. We have previously identified iron-responsive element–binding protein 2 (…
determinants. We have previously identified iron-responsive element–binding protein 2 (…