User profiles for Elizabeth Perez

Elizabeth Perez

Harvard University
Verified email at g.harvard.edu
Cited by 6119

[PDF][PDF] An integrative model of cellular states, plasticity, and genetics for glioblastoma

…, MKL Shaw, CM Hebert, J Dewitt, S Gritsch, EM Perez… - Cell, 2019 - cell.com
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable
and poorly understood tumor, but their precise characterization remains challenging. Here, …

[PDF][PDF] Cohesin loss eliminates all loop domains

…, SC Huang, BG St Hilaire, JM Engreitz, EM Perez… - Cell, 2017 - cell.com
The human genome folds to create thousands of intervals, called "contact domains," that
exhibit enhanced contact frequency within themselves. "Loop domains" form because of …

Local regulation of gene expression by lncRNA promoters, transcription and splicing

JM Engreitz, JE Haines, EM Perez, G Munson, J Chen… - Nature, 2016 - nature.com
Mammalian genomes are pervasively transcribed 1 , 2 to produce thousands of long non-coding
RNAs (lncRNAs) 3 , 4 . A few of these lncRNAs have been shown to recruit regulatory …

Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations

…, TA Patwardhan, TH Nguyen, M Kane, EM Perez… - Nature …, 2019 - nature.com
Enhancer elements in the human genome control how genes are expressed in specific cell
types and harbor thousands of genetic variants that influence risk for common diseases 1 , 2 , …

Systematic mapping of functional enhancer–promoter connections with CRISPR interference

…, R Anyoha, G Munson, SR Grossman, EM Perez… - Science, 2016 - science.org
Gene expression in mammals is regulated by noncoding elements that can affect physiology
and disease, yet the functions and target genes of most noncoding elements remain …

Isolation and characterization of mineral phosphate-solubilizing bacteria naturally colonizing a limonitic crust in the south-eastern Venezuelan region

E Perez, M Sulbaran, MM Ball, LA Yarzabal - Soil Biology and Biochemistry, 2007 - Elsevier
With the aim to explore the possible role of mineral phosphate-solubilizing bacteria (PSB) in
phosphorus (P) cycling in iron-rich, acidic soils, we conducted a survey of PSB naturally …

[PDF][PDF] Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

…, O Ashenberg, I Tirosh, S Gritsch, EM Perez… - Cell, 2021 - cell.com
T cells are critical effectors of cancer immunotherapies, but little is known about their gene
expression programs in diffuse gliomas. Here, we leverage single-cell RNA sequencing (RNA-…

Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function

G Notarangelo, JB Spinelli, EM Perez, GJ Baker… - Science, 2022 - science.org
Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …

[PDF][PDF] The proteomic landscape of triple-negative breast cancer

RT Lawrence, EM Perez, D Hernández, CP Miller… - Cell reports, 2015 - cell.com
Triple-negative breast cancer is a heterogeneous disease characterized by poor clinical
outcomes and a shortage of targeted treatment options. To discover molecular features of triple-…

Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

…, C Konrad, F Polverino, II Siempos, E Perez… - Nature medicine, 2016 - nature.com
Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic
determinants. We have previously identified iron-responsive element–binding protein 2 (…