Background Diagnosing asthma in children represents an important clinical challenge. There
is no single gold-standard test to confirm the diagnosis. Consequently, over- and under-…

Since the publication of the European Respiratory Society Task Force report in 2008, significant
new evidence has become available on the classification and management of preschool …

Background Many preschool children have wheeze or cough, but only some have asthma
later. Existing prediction tools are difficult to apply in clinical practice or exhibit methodological …

Mammalian airways are protected from infection by a thin film of airway surface liquid (ASL)
which covers airway epithelial surfaces and acts as a lubricant to keep mucus from adhering …

Background Early reports suggest that most children infected with severe acute respiratory
syndrome coronavirus 2 (“SARS-CoV-2”) have mild symptoms. What is not known is whether …

In patients with cystic fibrosis (CF), the isolation of filamentous fungi, in particular Aspergillus
spp. in the respiratory secretions is a common occurrence. Most of these patients do not …

Background Diffuse airway mucus obstruction is an important feature of severe and fatal
asthma. MUC5AC and MUC5B are the principal gel-forming mucins found in airway mucus. The …

Allergy to airway-colonising, thermotolerant, filamentous fungi represents a distinct eosinophilic
endotype of often severe lung disease. This endotype, which particularly affects adult …

Filamentous fungi are commonly isolated from the respiratory tract of CF patients, but their
clinical significance is uncertain and the reported incidence variable. We report on the degree …

Background Spirometry and fraction of exhaled nitric oxide (FeNO) are commonly used in
specialist centres to monitor children with asthma. The National Institute for Health and Care …