Background Azoles play an important role in the management of Aspergillus diseases.
Azole resistance is an emerging global problem in Aspergillus fumigatus, and may develop …

Background Resistance to triazoles was recently reported in Aspergillus fumigatus isolates
cultured from patients with invasive aspergillosis. The prevalence of azole resistance in A. …

Invasive aspergillosis due to multi-azole-resistant Aspergillus fumigatus has emerged in the
Netherlands since 1999, with 6·0–12·8% of patients harbouring resistant isolates. The …

The prevalence and spread of azole resistance in clinical Aspergillus fumigatus isolates in
the Netherlands are currently unknown. Therefore, we performed a prospective nationwide …

We reported the emergence of resistance to medical triazoles of Aspergillus fumigatus isolates
from patients with invasive aspergillosis. A dominant resistance mechanism was found, …

Molecular studies have shown that the majority of azole resistance in Aspergillus fumigatus
is associated with amino acid substitutions in the cyp51A gene. To obtain insight into azole …

Azole compounds are the primary therapy for patients with diseases caused by Aspergillus
fumigatus. However, prolonged treatment may cause resistance to develop, which is …

Four sequential Aspergillus fumigatus isolates from a patient with chronic granulomatous
disease (CGD) eventually failing azole-echinocandin combination therapy were investigated. …

This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in
two compost heaps with contrasting azole exposures: azole free and azole exposed. After …

Azole resistance is a major concern for treatment of infections with Aspergillus fumigatus.
Environmental resistance selection is a main route for Aspergillus spp. to acquire azole …