Asthma and chronic obstructive pulmonary disease are respiratory disorders and a major
global health problem with increasing incidence and severity. Genes originally associated with …

Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung
volume and is used to diagnose and monitor lung diseases. We performed genome-wide …

GDF-15 (growth differentiation factor 15) acts both as a stress-induced cytokine with diverse
actions at different body sites and as a cell-autonomous regulator linked to cellular …

Background Innate lymphoid cells (ILC) are a new family of innate immune cells that have
emerged as important regulators of tissue homeostasis and inflammation. However, limited …

Rationale: Aberrant expression of microRNAs (miRNAs) can have a detrimental role in disease
pathogenesis. Objectives: To identify dysregulated miRNAs in lung tissue of patients with …

Background Middle East respiratory syndrome coronavirus (MERS-CoV) causes pneumonia
with a relatively high case fatality rate in humans. Smokers and chronic obstructive …

Rationale: B cell–activating factor (BAFF) plays a major role in activation of B cells and in
adaptive humoral immune responses. In chronic obstructive pulmonary disease (COPD), …

Rationale: The B cell–attracting chemokine CXCL13 is an important mediator in the formation
of tertiary lymphoid organs (TLOs). Increased numbers of ectopic lymphoid follicles have …

Chronic obstructive pulmonary disease (COPD) is a highly prevalent respiratory disease
characterized by airflow limitation and chronic inflammation. MiR-155 is described as an …

Background Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of regulated
cell death (including apoptosis and necroptosis) and inflammation, both drivers of COPD …