In alpha-1 antitrypsin deficiency (AATD), the Z allele is present in 98% of cases with severe
disease, and knowledge of the frequency of this allele is essential from a public health …

Existing data on chronic obstructive pulmonary disease (COPD) prevalence are irregularly
distributed around the world, and in many geographic regions data are scarce or even …

Various studies have focused on understanding how the continuous positive air pressure (CPAP)
treatment improves the emotional state of obstructive sleep apnea patients, as well as …

Introducción La asociación entre la enfermedad pulmonar obstructiva crónica (EPOC) y la
ansiedad o la depresión no se conoce adecuadamente, y puede haber diferencias entre …

Existing data on COPD prevalence are limited or totally lacking in many regions of Europe.
The geographic information system inverse distance weighted (IDW) interpolation technique …

Background Given the high incidence of confirmed infection by SARS-CoV-2 and mortality
by COVID-19 in the Spanish population, its impact was analysed among persons with Cystic …

The alpha-1 antitrypsin (AAT) haplotype Pi*S, when inherited along with the Pi*Z haplotype
to form a Pi*SZ genotype, can be associated with pulmonary emphysema in regular smokers…

The percentage of α 1 -antitrypsin protease inhibitor ZZ (PiZZ) genotypes in patients with
COPD is controversial, with large differences among various studies. We aimed to estimate the …

Introduction The objective of this analysis was the evaluation of a new national circuit used
for diagnosing alpha1 antitrypsin deficiency (AATD) based on multiplex technology using …

Background The ORBE II study aimed to describe the characteristics and clinical outcomes
of adult patients with severe eosinophilic asthma (SEA) treated with benralizumab in a real-…