User profiles for Frauke Christ

Frauke Christ

Innovation Manager KU Leuven
Verified email at kuleuven.be
Cited by 7614

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

F Christ, A Voet, A Marchand, S Nicolet… - Nature chemical …, 2010 - nature.com
Lens epithelium–derived growth factor (LEDGF/p75) is a cellular cofactor of HIV-1 integrase
that promotes viral integration by tethering the preintegration complex to the chromatin. By …

[PDF][PDF] Transportin-SR2 imports HIV into the nucleus

F Christ, W Thys, J De Rijck, R Gijsbers, A Albanese… - Current Biology, 2008 - cell.com
Background The human immunodeficiency virus type 1 (HIV-1) and other lentiviruses have
the capacity to infect nondividing cells like macrophages. This requires import of the …

[HTML][HTML] Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impairedin Chromosome Tethering and HIV-1Replication

…, F Moisant, L Ben-Slama, M Witvrouw, F Christ… - Journal of Biological …, 2005 - ASBMB
The insertion of a DNA copy of its RNA genome into a chromosome of the hostcell is mediated
by the viral integrase with the help of mostlyuncharacterized cellular cofactors. We have …

[HTML][HTML] The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

…, R Benarous, Y Engelborghs, F Christ… - Journal of Biological …, 2005 - ASBMB
We have previously shown that the p75 isoform of the transcriptional co-activator lens
epithelium-derived growth factor (LEDGF) interacts tightly with human immunodeficiency virus (HIV…

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

L Vandekerckhove, F Christ, B Van Maele… - Journal of …, 2006 - Am Soc Microbiol
After identifying the interaction between the transcriptional coactivator lens epithelium-derived
growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) …

Cellular co-factors of HIV-1 integration

…, K Busschots, L Vandekerckhove, F Christ… - Trends in biochemical …, 2006 - cell.com
To achieve productive infection, the reverse transcribed cDNA of human immunodeficiency
virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this …

Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization

F Christ, S Shaw, J Demeulemeester… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Targeting the HIV integrase (HIV IN) is a clinically validated approach for designing novel
anti-HIV therapies. We have previously described the discovery of a novel class of integration …

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure− activity relationship of a class of human immunodeficiency virus type 1 integrase …

…, M Witvrouw, M Michiels, F Christ… - Journal of medicinal …, 2008 - ACS Publications
A set of 4-quinolone-3-carboxylic acids bearing different substituents on the condensed
benzene ring was designed and synthesized as potential HIV-1 integrase inhibitors structurally …

[HTML][HTML] LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

…, J De Rijck, J Hendrix, N Bannert, R Gijsbers, F Christ… - Retrovirology, 2013 - Springer
Background LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens
epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 …

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

…, J Vercammen, Y Engelborghs, F Christ… - Journal of …, 2006 - Am Soc Microbiol
We initially identified lens epithelium-derived growth factor/p75 (LEDGF/p75) as a binding
partner of human immunodeficiency virus type 1 (HIV-1) integrase. To investigate the role of …