Background The relevance to coronary heart disease (CHD) of cytokines that govern
inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such …

Importance Interstitial lung abnormalities have been associated with lower 6-minute walk
distance, diffusion capacity for carbon monoxide, and total lung capacity. However, to our …

Background A large number of observational studies have reported harmful effects of low 25-hydroxyvitamin
D (25OHD) levels on non-skeletal outcomes. We performed a systematic …

Background Associations between circulating markers of dysglycaemia and coronary heart
disease (CHD) risk in people without diabetes have not been reliably characterised. We …

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

Background C-reactive protein is an inflammatory marker believed to be of value in the
prediction of coronary events. We report data from a large study of C-reactive protein and other …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Blood pressure is a major cardiovascular disease risk factor. To date, few variants associated
with interindividual blood pressure variation have been identified and replicated. Here we …