Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis

JD Chalmers, KL Moffitt, G Suarez-Cuartin… - American journal of …, 2017 - atsjournals.org
Rationale: Sputum neutrophil elastase and serum desmosine, which is a linked marker of
endogenous elastin degradation, are possible biomarkers of disease severity and progression …

[HTML][HTML] Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

…, EG Pumphrey, AJ Cassidy, G Suarez-Cuartin… - Journal of Allergy and …, 2018 - Elsevier
Background Neutrophil extracellular traps (NETs) have been observed in the airway in
patients with chronic obstructive pulmonary disease (COPD), but their clinical and …

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study

…, J Pollock, YH Giam, G Suarez-Cuartin… - The lancet Respiratory …, 2021 - thelancet.com
Background Bronchiectasis is predominantly a neutrophilic inflammatory disease. There are
no established therapies that directly target neutrophilic inflammation because little is …

[HTML][HTML] Efficacy and Safety of Dry Powder Antibiotics: A Narrative Review

D de la Rosa-Carrillo, G Suárez-Cuartín… - Journal of Clinical …, 2023 - mdpi.com
The use of inhaled antibiotics was initially almost exclusively confined to patients with cystic
fibrosis (CF). However, it has been extended in recent decades to patients with non-CF …

[HTML][HTML] Pre-existing autoantibodies neutralizing high concentrations of type I interferons in almost 10% of COVID-19 patients admitted to intensive care in Barcelona

…, MÁ Gordillo-Benitez, G Suarez-Cuartin… - Journal of clinical …, 2021 - Springer
Background It is important to predict which patients infected by SARS-CoV-2 are at higher
risk of life-threatening COVID-19. Several studies suggest that neutralizing auto-antibodies (…

[HTML][HTML] Diagnostic challenges of bronchiectasis

G Suarez-Cuartin, JD Chalmers, O Sibila - Respiratory medicine, 2016 - Elsevier
Bronchiectasis is a condition of increasing incidence and prevalence around the world. Many
different diseases have been associated with bronchiectasis, and their treatment can differ …

[HTML][HTML] Beneficial effect of corticosteroids in preventing mortality in patients receiving tocilizumab to treat severe COVID-19 illness

…, X Solanich, M Gasa, G Suarez-Cuartin… - International Journal of …, 2020 - Elsevier
Objectives To assess the characteristics and risk factors for mortality in patients with severe
coronavirus disease-2019 (COVID-19) treated with tocilizumab (TCZ), alone or in …

[HTML][HTML] Muscle MRI findings in childhood/adult onset pompe disease correlate with muscle function

…, I Pedrosa, A Alejaldre, M Mayos, G Suarez-Cuartin… - PloS one, 2016 - journals.plos.org
Objectives Enzyme replacement therapy has shown to be effective for childhood/adult onset
Pompe disease (AOPD). The discovery of biomarkers useful for monitoring disease …

[HTML][HTML] Identification of airway bacterial colonization by an electronic nose in chronic obstructive pulmonary disease

…, J Giner, JL Merino, G Suarez-Cuartin… - Respiratory …, 2014 - Elsevier
Background Airway bacterial colonization by potentially pathogenic microorganisms occurs
in a proportion of patients with Chronic Obstructive Pulmonary Disease (COPD). It increases …

Inhaled Colistimethate Sodium in the Management of Patients with Bronchiectasis Infected by Pseudomonas aeruginosa: A Narrative Review of Current Evidence

D De la Rosa-Carrillo, G Suárez-Cuartín… - Infection and Drug …, 2022 - Taylor & Francis
International guidelines on the treatment of bronchiectasis indicate that the use of inhaled
antibiotics is effective, especially in symptomatic chronic bronchial infection (CBI) due to …