Chronic inflammation is linked to carcinogenesis in several organ systems. In the lungs, NF-κB,
a central effector of inflammatory responses, is frequently activated in non-small-cell lung …

Recent reports have linked mutations in the surfactant protein C gene (SFTPC) to familial
forms of pulmonary fibrosis, but it is uncertain whether deficiency of mature SP-C contributes to …

… Correspondence and requests for reprints should be addressed to Georgios T. Stathopoulos,
MD, Ph.D., Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology…

Malignant pleural effusion (MPE) is a common but serious condition that is related with poor
quality of life, morbidity and mortality. Its incidence and associated healthcare costs are …

Tumor necrosis factor (TNF)-α is present in the microenvironment of human tumors, including
malignant pleural effusion (MPE). Although the cytokine is produced in the pleural cavity by …

Because fibroblasts produce collagen and other extracellular matrix components that are
deposited during tissue fibrosis, defining the behavior of these cells is critical to understanding …

Tumor-associated macrophages (TAMs) influence lung tumor development by inducing
immunosuppression. Transcriptome analysis of TAMs isolated from human lung tumor tissues …

Simple Summary Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and
represents the deadliest human cancer, affecting current-, ex-, and even non-smokers. LUAD is …

Macrophages have established roles in tumor growth and metastasis, but information about
their role in lung tumor promotion is limited. To assess the role of macrophages in lung …

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To
this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and …