User profiles for Graham G. Giles

Graham G Giles

Cancer Council Victoria
Verified email at cancervic.org.au
Cited by 203458

Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians

…, MW Butler, SK Goergen, GB Byrnes, GG Giles… - Bmj, 2013 - bmj.com
Objective To assess the cancer risk in children and adolescents following exposure to low
dose ionising radiation from diagnostic computed tomography (CT) scans. Design Population …

Genome-wide association study identifies novel breast cancer susceptibility loci

…, JL Hopper, M McCredie, M Southey, GG Giles… - Nature, 2007 - nature.com
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

[HTML][HTML] Socioeconomic status and the 25× 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1· 7 million men and …

…, G Costa, C Delpierre, S Fraga, M Goldberg, GG Giles… - The Lancet, 2017 - thelancet.com
Background In 2011, WHO member states signed up to the 25 × 25 initiative, a plan to cut
mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic …

[PDF][PDF] REVEL: an ensemble method for predicting the pathogenicity of rare missense variants

…, O Cussenot, G Cancel-Tassin, GG Giles… - The American Journal of …, 2016 - cell.com
The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data. …

Large-scale genotyping identifies 41 new loci associated with breast cancer risk

…, GS Dite, C Apicella, H Tsimiklis, GG Giles, G Severi… - Nature …, 2013 - nature.com
Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for ∼9…

Association analysis identifies 65 new breast cancer risk loci

…, MM Gaudet, V Georgoulias, GG Giles, G Glendon… - Nature, 2017 - nature.com
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

[HTML][HTML] Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis …

…, JE Olson, L Baglietto, GG Giles, G Severi… - PLoS …, 2010 - journals.plos.org
Background Immunohistochemical markers are often used to classify breast cancer into
subtypes that are biologically distinct and behave differently. The aim of this study was to …

Multiple newly identified loci associated with prostate cancer susceptibility

RA Eeles, Z Kote-Jarai, GG Giles, AAA Olama, M Guy… - Nature …, 2008 - nature.com
Prostate cancer is the most common cancer affecting males in developed countries. It shows
consistent evidence of familial aggregation, but the causes of this aggregation are mostly …

[PDF][PDF] Polygenic risk scores for prediction of breast cancer and breast cancer subtypes

…, GG Giles, IR Gilyazova, G Glendon… - The American Journal of …, 2019 - cell.com
Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …

[HTML][HTML] Iron-Overload–Related Disease in HFE Hereditary Hemochromatosis

…, GJ Anderson, MC Southey, GG Giles… - … England Journal of …, 2008 - Mass Medical Soc
Background Most persons who are homozygous for C282Y, the HFE allele most commonly
asssociated with hereditary hemochromatosis, have elevated levels of serum ferritin and …