Recent advances in 3D bioprinting allow for generating intricate structures with dimensions
relevant for human tissue, but suitable bioinks for producing translationally relevant tissue …

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and
limited therapeutic options. The incidence of IPF increases with age, and ageing-related …

Idiopathic pulmonary fibrosis (IPF) is a devastating chronic interstitial lung disease (ILD)
characterized by lung tissue scarring and high morbidity. Lung epithelial injury, myofibroblast …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive
injury and reprogramming of the lung epithelium are thought to be critical drivers of disease …

Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial
lung disease, and lung cancer, are among the leading causes of morbidity globally and …

Rationale: Chronic obstructive pulmonary disease (COPD), in particular emphysema, is
characterized by loss of parenchymal alveolar tissue and impaired tissue repair. Wingless and …

Repeated injury of the lung epithelium is proposed to be the main driver of idiopathic pulmonary
fibrosis (IPF). However, available therapies do not specifically target the epithelium and …

Translation of novel discoveries to human disease is limited by the availability of human
tissue-based models of disease. Precision-cut lung slices (PCLS) used as 3D lung tissue …

Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death.
Underlying biological processes involve induced massive deposition of extracellular matrix (…

Mechanisms of injury and repair in alveolar epithelial cells (AECs) are critically involved in
the progression of various lung diseases including idiopathic pulmonary fibrosis (IPF). …