Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis
OBJECTIVES: Exposure to passive smoke is a common and avoidable risk factor for wheeze
and asthma in children. Substantial growth in the prospective cohort study evidence base …
and asthma in children. Substantial growth in the prospective cohort study evidence base …
Dysregulation of Antiviral Function of CD8+ T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1–PD-L1 Axis
RT McKendry, CM Spalluto, H Burke… - American journal of …, 2016 - atsjournals.org
Rationale: Patients with chronic obstructive pulmonary disease (COPD) are susceptible to
respiratory viral infections that cause exacerbations. The mechanisms underlying this …
respiratory viral infections that cause exacerbations. The mechanisms underlying this …
Noninvasive ventilation for COVID-19-associated acute hypoxaemic respiratory failure: experience from a single centre
…, D Land, S Fletcher, A Freeman, H Burke… - British journal of …, 2020 - bjanaesthesia.org
1. Sorbello M, El-Boghdadly K, Di Giacinto I, et al. The Italian coronavirus disease 2019
outbreak: recommendations from clinical practice. Anaesthesia 2020; 75: 724e32 2. Bhatraju PK, …
outbreak: recommendations from clinical practice. Anaesthesia 2020; 75: 724e32 2. Bhatraju PK, …
Dynamics of IFN-β responses during respiratory viral infection. Insights for therapeutic strategies
Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients
with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component …
with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component …
A multidisciplinary team case management approach reduces the burden of frequent asthma admissions
H Burke, J Davis, S Evans, L Flower, A Tan… - ERJ open …, 2016 - Eur Respiratory Soc
Up to 10% of asthmatics have “difficult asthma”; however, they account for 80% of asthma-related
expenditure and run the highest risk of acute severe exacerbations. An estimated 75% …
expenditure and run the highest risk of acute severe exacerbations. An estimated 75% …
[HTML][HTML] Risk factors for persistent abnormality on chest radiographs at 12-weeks post hospitalisation with PCR confirmed COVID-19
TJM Wallis, E Heiden, J Horno, B Welham, H Burke… - Respiratory …, 2021 - Springer
Background The long-term consequences of COVID-19 remain unclear. There is concern a
proportion of patients will progress to develop pulmonary fibrosis. We aimed to assess the …
proportion of patients will progress to develop pulmonary fibrosis. We aimed to assess the …
Using novel computed tomography analysis to describe the contribution and distribution of emphysema and small airways disease in chronic obstructive pulmonary …
K Ostridge, K Gove, KHW Paas, H Burke… - Annals of the …, 2019 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation,
caused by emphysema and small airways disease (SAD). Computed tomography (CT) …
caused by emphysema and small airways disease (SAD). Computed tomography (CT) …
Wave comparisons of clinical characteristics and outcomes of COVID-19 admissions-Exploring the impact of treatment and strain dynamics
Objectives Dexamethasone has now been incorporated into the standard of care for COVID-19
hospital patients. However, larger intensive care unit studies have failed to show …
hospital patients. However, larger intensive care unit studies have failed to show …
[HTML][HTML] MonaGO: a novel gene ontology enrichment analysis visualisation system
Background Gene ontology (GO) enrichment analysis is frequently undertaken during
exploration of various -omics data sets. Despite the wide array of tools available to biologists to …
exploration of various -omics data sets. Despite the wide array of tools available to biologists to …
[HTML][HTML] Dysregulation of COVID-19 related gene expression in the COPD lung
Background Chronic obstructive pulmonary disease (COPD) patients are at increased risk
of poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated Severe …
of poor outcome from Coronavirus disease (COVID-19). Early data suggest elevated Severe …