Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of …

… of HL60 cells with sub-toxic concentrations of the telomerase/reverse transcriptase inhibitor
AZT leads rather to the selection of AZT-resistant cells than to senescence induction (JFRiou …

Progress in cancer chemotherapy has been made owing to the discovery and development
of drugs that have new structures, new mechanisms of action, and high levels of …

Since December 2019, China has been experiencing a large outbreak of a novel coronavirus
(2019-nCoV) which can cause respiratory disease and severe pneumonia. We estimated …

DOPAMINE receptors are classified into D l and D 2 subtypes on the basis of their
pharmacological properties and the intracellular responses they mediate 1 . The cerebral D 2 …

Members of the peroxisome proliferator–activated receptor (PPAR) family might be involved
in pathologies with altered lipid metabolism. They participate in the control of the expression …

Telomeres of human chromosomes contain a G-rich 3′-overhang that adopts an intramolecular
G-quadruplex structure in vitro which blocks the catalytic reaction of telomerase. Agents …

We describe a novel synthetic small molecule which shows an unprecedented stabilization
of the human telomeric G-quadruplex with high selectivity relative to double-stranded DNA. …

Thirty-one abdominal fascial wound dehiscences occurred in 2,761 patients undergoing
major abdominal surgery during a 5-year period (1%). Twenty-two specific local and systemic …

Background The new Middle East respiratory syndrome coronavirus (MERS-CoV) infection
shares many clinical, epidemiological, and virological similarities with that of severe acute …