Background Chronic obstructive pulmonary disease (COPD) is a major public health
problem associated with long-term exposure to toxic gases and particles. We examined the …

We have wedged a small catheter in airways 2 to 3 mm in diameter in excised human lungs
to have measure airway resistance central (R c ) and peripheral (R p ) to this site. In five …

The airflow limitation that defines chronic obstructive pulmonary disease (COPD) is the
result of a prolonged time constant for lung emptying, caused by increased resistance of the …

Background The major sites of obstruction in chronic obstructive pulmonary disease (COPD)
are small airways (<2 mm in diameter). We wanted to determine whether there was a …

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
airway inflammation that is greater in patients with advanced disease. We asked whether there …

This study was designed to determine the potential importance of airway wall thickening in
the pathogenesis of the excess airways narrowing of asthma. The airways in postmortem …

Despite the considerable progress in the classification of the idiopathic interstitial pneumonias
(IIPs), the lack of an international standard has resulted in variable and confusing …

Elevated levels of ambient particulate matter (PM 10 ) have been associated with increased
cardiopulmonary morbidity and mortality. We previously showed that the deposition of …

The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate
and adaptive inflammatory immune response to the inhalation of toxic particles and gases. …

Chronic obstructive pulmonary disease (COPD) is characterized by the presence of airflow
obstruction caused by emphysema or airway narrowing, or both. Low attenuation areas (LAA) …