[HTML][HTML] The impact of open versus closed format ICU admission practices on the outcome of high risk surgical patients: a cohort analysis

FJ van der Sluis, C Slagt, B Liebman, J Beute… - BMC surgery, 2011 - Springer
Background In the year 2000, the organizational structure of the ICU in the Zaandam Medical
Centre (ZMC) changed from an open to a closed format ICU. The objective of this study …

[HTML][HTML] A pathophysiological role of PDE3 in allergic airway inflammation

J Beute, M Lukkes, EP Koekoek, H Nastiti, K Ganesh… - JCI insight, 2018 - ncbi.nlm.nih.gov
Phosphodiesterase 3 (PDE3) and PDE4 regulate levels of cyclic AMP, which are critical in
various cell types involved in allergic airway inflammation. Although PDE4 inhibition …

Cardiac output derived from arterial pressure waveform analysis without calibration vs. thermodilution in septic shock: evolving accuracy of software versions

C Slagt, J Beute, M Hoeksema, I Malagon… - European Journal of …, 2010 - journals.lww.com
Methods Nine patients who received a pulmonary artery catheter and were on mechanical
ventilation and in sinus rhythm were monitored by the FloTrac/Vigileo. Paired cardiac output …

Cardiac output measured by uncalibrated arterial pressure waveform analysis by recently released software version 3.02 versus thermodilution in septic shock

C Slagt, MA De Leeuw, J Beute, E Rijnsburger… - Journal of clinical …, 2013 - Springer
To evaluate the 3.02 software version of the FloTrac/Vigileo™ system for estimation of
cardiac output by uncalibrated arterial pressure waveform analysis, in septic shock. Nineteen …

[HTML][HTML] PDE3 inhibition reduces epithelial mast cell numbers in allergic airway inflammation and attenuates degranulation of basophils and mast cells

J Beute, K Ganesh, H Nastiti, R Hoogenboom… - Frontiers in …, 2020 - frontiersin.org
Epithelial mast cells are generally present in the airways of patients with allergic asthma
that are inadequately controlled. Airway mast cells (MCs) are critically involved in allergic …

PDE3-inhibitor enoximone prevented mechanical ventilation in patients with SARS-CoV-2 pneumonia

J Beute, P Boermans, B Benraad, J Telman… - Experimental lung …, 2021 - Taylor & Francis
Background Standard care in severe SARS-CoV-2 pneumonia complicated by severe
dyspnea and respiratory failure, consists of symptom reduction, ultimately supported by …

Phosphodiesterase 3 and 4 inhibition: facing a bright future in asthma control

J Beute, V Manganiello, A KleinJan - Approach Based on …, 2018 - books.google.com
A recent status on asthmaticus multiple case report by Beute demonstrated the beneficial
effects of phosphodiesterase III (PDE3) and phosphodiesterase IV (PDE4) inhibition. This …

[HTML][HTML] Oral enoximone allows the reduction and discontinuation of inhaled steroids and beta2 agonists in asthmatic children

J Beute, A KleinJan - International Journal of Pediatrics and Adolescent …, 2022 - Elsevier
In the last two decades, improvement on asthma treatment has been merely marginal for both
adults and children; inhaled corticosteroids (ICS) combined with β-2-mimetics remain the …

(Oral) enoximone in asthma

J Beute - ERJ Open Research, 2020 - Eur Respiratory Soc
The Enoximone in status asthmaticus letter [1] referenced our case series from the
Netherlands wherein intravenous enoximone (Perfan, Carinopharm, Germany) reversed status …

[HTML][HTML] Evaluation of Real-Life Investigational Use of Enoximone in Asthma, the Third Step in Drug Repurposing: A Preliminary Report

J Beute, P Boermans, A KleinJan - Canadian Respiratory Journal, 2021 - hindawi.com
Background. The population of uncontrolled asthma patients represents a large therapeutic
burden. The PDE3-inhibitor enoximone is a strong and quick bronchodilator and is known to …