We have investigated whether restoration of the balance between neutrophil elastase and its
inhibitor, α 1 -antitrypsin, can prevent the progression of pulmonary emphysema in patients …

Cigarette smoking results in oxidative stress and inflammation in the lungs, which are
involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 4-Hydroxy-2-…

Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death,
with cigarette smoking among the main risk factors. Hallmarks of COPD include chronic …

Chronic airways inflammation is one of the features of chronic obstructive pulmonary
disease (COPD). We demonstrated previously that bronchiolar epithelium in COPD contains …

α 1 -antitrypsin deficiency (AATD) is the most common hereditary disorder in adults. It is
associated with an increased risk of developing pulmonary emphysema and liver disease. The …

Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that manifests as pulmonary
emphysema, liver cirrhosis and, rarely, as the skin disease panniculitis, and is characterized by …

Since the first American Thoracic Society statement regarding the diagnosis and management
of severe alpha-1 antitrypsin (AAT) deficiency in 1989 (1) and the initial Canadian …

FEV 1 is fundamental to the diagnosis and staging of chronic obstructive pulmonary disease.
In emphysema, airflow obstruction usually coexists with impairment of gas exchange, but …

Endoplasmic reticulum (ER) stress is increasingly recognized as an important mechanism
in a wide range of diseases including cystic fibrosis, alpha-1 antitrypsin deficiency, …

… Jan Stolk has served on company advisory board meetings of various companies and served
as consultant to some of them. Fees were directly donated to the bank account of the Alpha…