The kisspeptin/gonadotropin-releasing hormone pathway and molecular signaling of puberty in fish

AL Filby, R Aerle, JW Duitman… - Biology of …, 2008 - academic.oup.com
The mechanisms underlying the initiation of puberty in fish are poorly understood, and whether
the Kiss1 receptor (Kiss1r; previously designated G protein-coupled receptor 54; GPR54) …

Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19

…, J Verhoeff, S Van Asten, H Bontkes, S Blok, J Duitman… - Thorax, 2021 - thorax.bmj.com
Background Knowledge of the pathophysiology of COVID-19 is almost exclusively derived
from studies that examined the immune response in blood. We here aimed to analyse the …

Protease‐activated receptor‐1 drives pancreatic cancer progression and chemoresistance

KCS Queiroz, K Shi, JW Duitman… - … journal of cancer, 2014 - Wiley Online Library
Protease activated receptor (PAR)‐1 expression in tumor cells is associated with disease
progression and overall survival in a variety of cancers of epithelial origin; however, the …

[HTML][HTML] Pulmonary procoagulant and innate immune responses in critically ill COVID-19 patients

…, TDY Reijnders, I Jongerius, JW Duitman… - Frontiers in …, 2021 - frontiersin.org
Rationale Systemic activation of procoagulant and inflammatory mechanisms has been
implicated in the pathogenesis of COVID-19. Knowledge of activation of these host response …

[HTML][HTML] Matrix metalloproteases in pancreatic ductal adenocarcinoma: key drivers of disease progression?

EJ Slapak, JW Duitman, C Tekin, MF Bijlsma, CA Spek - Biology, 2020 - mdpi.com
Pancreatic cancer is a dismal disorder that is histologically characterized by a dense fibrotic
stroma around the tumor cells. As the extracellular matrix comprises the bulk of the stroma, …

The impaired proteases and anti-proteases balance in Idiopathic Pulmonary Fibrosis

A Menou, JW Duitman, B Crestani - Matrix Biology, 2018 - Elsevier
Idiopathic Pulmonary Fibrosis (IPF) is a devastating chronic, progressive and irreversible
disease that remains refractory to current therapies. Matrix metalloproteinases (MMPs) and …

Human airway trypsin-like protease, a serine protease involved in respiratory diseases

A Menou, JW Duitman, P Flajolet… - … of Physiology-Lung …, 2017 - journals.physiology.org
More than 2% of all human genes are coding for a complex system of more than 700
proteases and protease inhibitors. Among them, serine proteases play extraordinary, diverse …

[HTML][HTML] Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID‐19

…, K de Buck, AR Schuurman, JW Duitman… - European journal of …, 2021 - ncbi.nlm.nih.gov
Despite high levels of CXCR3 ligands in mechanically ventilated COVID‐19 patients, BALF
CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+, likely due to high CCL20 …

Targeting protease activated receptor-1 with P1pal-12 limits bleomycin-induced pulmonary fibrosis

C Lin, JW Duitman, J Daalhuisen, M Ten Brink… - Thorax, 2014 - thorax.bmj.com
Background Idiopathic pulmonary fibrosis is the most devastating fibrotic diffuse parenchymal
lung disease which remains refractory to pharmacological therapies. Therefore, novel …

[HTML][HTML] Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice

M Waasdorp, JW Duitman, S Florquin, CA Spek - Scientific reports, 2016 - nature.com
Endogenously administered activated protein C ameliorates diabetic nephropathy (DN) in a
protease-activated receptor-1 (PAR-1)-dependent manner, suggesting that PAR-1 activation …