Background Bronchiectasis is predominantly a neutrophilic inflammatory disease. There are
no established therapies that directly target neutrophilic inflammation because little is …

… Dicker PhD a , Jeffrey TJ Huang PhD a , Mike Lonergan PhD a , Holly R. Keir BSc a ,
Christopher J. Fong MBChB a , Brandon Tan MBChB a , Andrew J. …

The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase
that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and …

R-loops are stable nucleic acid structures that have important physiological functions, but
which also pose a significant threat to genomic stability. Increased R-loops cause replication …

Background Infection is a key component of bronchiectasis pathophysiology. Characterisation
of the microbiome offers a higher degree of sensitivity and resolution than does traditional …

Background Although an increased concentration of degraded elastin products in patients
with chronic obstructive pulmonary disease (COPD) has been reported for many years, its …

Elastin degradation is a key feature of emphysema and may have a role in the
pathogenesis of atherosclerosis associated with chronic obstructive pulmonary disease (COPD). …

We present first quantitative three-dimensional (3D) data sets recorded using optical
coherence elastography (OCE) for the diagnosis and detection of prostate cancer (PCa). 120 …

Rationale: PZP (pregnancy zone protein) is a broad-spectrum immunosuppressive protein
believed to suppress T-cell function during pregnancy to prevent fetal rejection. It has not …

Background In cystic fibrosis (CF), cross-sectional studies have reported sputum matrix
metalloproteinase (MMP)-9 to be elevated and negatively correlated with FEV 1 . This …