Generation of pathogenic TH17 cells in the absence of TGF-β signalling

…, XP Yang, CM Tato, MJ McGeachy, JE Konkel… - Nature, 2010 - nature.com
CD4 + T-helper cells that selectively produce interleukin (IL)-17 (T H 17), are critical for host
defence and autoimmunity 1 , 2 , 3 , 4 . Although crucial for T H 17 cells in vivo 5 , 6 , IL-23 …

[HTML][HTML] GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

…, JR Grainger, N Bouladoux, JE Konkel… - The Journal of …, 2011 - Am Soc Clin Investig
Tregs not only keep immune responses to autoantigens in check, but also restrain those
directed toward pathogens and the commensal microbiota. Control of peripheral immune …

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

…, S Tamoutounour, JE Allen, JE Konkel… - Journal of Experimental …, 2018 - rupress.org
A defining feature of resident gut macrophages is their high replenishment rate from blood
monocytes attributed to tonic commensal stimulation of this site. In contrast, almost all other …

[PDF][PDF] Hydrogen sulfide promotes Tet1-and Tet2-mediated Foxp3 demethylation to drive regulatory T cell differentiation and maintain immune homeostasis

R Yang, C Qu, Y Zhou, JE Konkel, S Shi, Y Liu, C Chen… - Immunity, 2015 - cell.com
Regulatory T (Treg) cells are essential for maintenance of immune homeostasis. Here we
found that hydrogen sulfide (H 2 S) was required for Foxp3 + Treg cell differentiation and …

[HTML][HTML] Tissue-specific immunity at the oral mucosal barrier

NM Moutsopoulos, JE Konkel - Trends in immunology, 2018 - cell.com
The oral mucosal barrier is constantly exposed to a plethora of triggers requiring immune
control, including a diverse commensal microbiome, ongoing damage from mastication, and …

[PDF][PDF] Alterations in T and B cell function persist in convalescent COVID-19 patients

…, A Simpson, JR Grainger, T Hussell, JE Konkel… - Med, 2021 - cell.com
Background Emerging studies indicate that some coronavirus disease 2019 (COVID-19)
patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however…

[HTML][HTML] Characterization of the human immune cell network at the gingival barrier

N Dutzan, JE Konkel, T Greenwell-Wild… - Mucosal …, 2016 - Elsevier
The oral mucosa is a barrier site constantly exposed to rich and diverse commensal
microbial communities, yet little is known of the immune cell network maintaining immune …

[PDF][PDF] Bone-marrow-resident NK cells prime monocytes for regulatory function during infection

…, DM da Fonseca, N Bouladoux, C Wilhelm, JE Konkel… - Immunity, 2015 - cell.com
Tissue-infiltrating Ly6C hi monocytes play diverse roles in immunity, ranging from pathogen
killing to immune regulation. How and where this diversity of function is imposed remains …

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

ER Mann, M Menon, SB Knight, JE Konkel… - Science …, 2020 - science.org
COVID-19 pathogenesis is associated with an exaggerated immune response. However,
the specific cellular mediators and inflammatory components driving diverse clinical disease …

[PDF][PDF] On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier

…, SA Jones, G Trinchieri, PI Diaz, Y Belkaid, JE Konkel… - Immunity, 2017 - cell.com
Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to
ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host …