Background Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease characterised by
progressive scarring leading to alveolar stiffness, reduced lung capacity, and impeded gas …

Amiloride-sensitive epithelial Na + channels (ENaCs) can be formed by different combinations
of four homologous subunits, named α, β, γ, and δ. In addition to providing an apical entry …

We present osprey 3.0, a new and greatly improved release of the osprey protein design
software. Osprey 3.0 features a convenient new Python interface, which greatly improves its …

Background Acute respiratory distress syndrome (ARDS) is a lung inflammatory process
caused mainly by sepsis. Most previous studies that identified genetic risks for ARDS focused …

The zebrafish has become a mainstream vertebrate model that is relevant for many disciplines
of scientific study. Zebrafish are especially well suited for forward genetic analysis of …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by
limited treatment options and high mortality. A better understanding of the molecular drivers of …

The kidney is comprised of nephrons – epithelial tubes with specialized segments that
reabsorb and secrete solutes, perform osmoregulation, and produce urine. Different nephron …

Background Specific common and rare single nucleotide variants (SNVs) increase the
likelihood of developing sporadic idiopathic pulmonary fibrosis (IPF). We performed target-…

Computational protein design (CPD) algorithms that compute binding affinity, K a , search for
sequences with an energetically favorable free energy of binding. Recent work shows that …

Most causal variants of Mendelian diseases are exonic. Whole‐exome sequencing (WES)
has become the diagnostic gold standard, but causative variant prioritization constitutes a …